Current State of and Future Opportunities for Prediction in Microbiome Research: Report from the Mid-Atlantic Microbiome Meet-up in Baltimore on 9 January 2019.

bioinformatics conceptual models machine learning metagenomics microbiome prediction quantitative models

Journal

mSystems
ISSN: 2379-5077
Titre abrégé: mSystems
Pays: United States
ID NLM: 101680636

Informations de publication

Date de publication:
08 Oct 2019
Historique:
entrez: 10 10 2019
pubmed: 9 10 2019
medline: 9 10 2019
Statut: epublish

Résumé

Accurate predictions across multiple fields of microbiome research have far-reaching benefits to society, but there are few widely accepted quantitative tools to make accurate predictions about microbial communities and their functions. More discussion is needed about the current state of microbiome analysis and the tools required to overcome the hurdles preventing development and implementation of predictive analyses. We summarize the ideas generated by participants of the Mid-Atlantic Microbiome Meet-up in January 2019. While it was clear from the presentations that most fields have advanced beyond simple associative and descriptive analyses, most fields lack essential elements needed for the development and application of accurate microbiome predictions. Participants stressed the need for standardization, reproducibility, and accessibility of quantitative tools as key to advancing predictions in microbiome analysis. We highlight hurdles that participants identified and propose directions for future efforts that will advance the use of prediction in microbiome research.

Identifiants

pubmed: 31594828
pii: 4/5/e00392-19
doi: 10.1128/mSystems.00392-19
pmc: PMC6787564
pii:
doi:

Types de publication

Journal Article

Langues

eng

Informations de copyright

Copyright © 2019 Sakowski et al.

Références

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5756-61
pubmed: 25902536
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Nat Methods. 2017 Nov;14(11):1063-1071
pubmed: 28967888
Science. 2010 Mar 19;327(5972):1509-11
pubmed: 20185684
Nature. 2012 Jun 13;486(7402):215-21
pubmed: 22699610
Nat Biotechnol. 2011 May;29(5):415-20
pubmed: 21552244
PLoS Comput Biol. 2016 Jul 11;12(7):e1004977
pubmed: 27400279
Nat Methods. 2018 Oct;15(10):796-798
pubmed: 30275573
BMC Microbiol. 2012 Jul 30;12:158
pubmed: 22846661
Nat Methods. 2018 Jul;15(7):475-476
pubmed: 29967506
Cell. 2015 Nov 19;163(5):1079-1094
pubmed: 26590418
Cell Metab. 2015 Aug 4;22(2):320-31
pubmed: 26244934
Nat Commun. 2017 Dec 5;8(1):1784
pubmed: 29209090
BMJ Open Gastroenterol. 2019 May 27;6(1):e000297
pubmed: 31275588
Nat Med. 2019 Apr;25(4):679-689
pubmed: 30936547
Nature. 2017 Nov 23;551(7681):457-463
pubmed: 29088705
Nat Methods. 2012 Apr 15;9(6):621-5
pubmed: 22504588
Microbiome. 2018 Nov 5;6(1):197
pubmed: 30396371
Cell. 2014 Feb 27;156(5):1045-59
pubmed: 24581500
ISME J. 2015 Jan;9(1):166-79
pubmed: 25072414
Nature. 2016 Dec 22;540(7634):544-551
pubmed: 27906159
Front Microbiol. 2015 Aug 04;6:771
pubmed: 26300854
Nucleic Acids Res. 2012 Jan;40(Database issue):D123-9
pubmed: 22086953
JCI Insight. 2018 Oct 4;3(19):
pubmed: 30282817
Microbiome. 2018 Sep 18;6(1):165
pubmed: 30227897
mBio. 2015 May 12;6(3):e00326-15
pubmed: 25968645
Gastroenterology. 2011 Nov;141(5):1782-91
pubmed: 21741921
Curr Opin Microbiol. 2018 Aug;44:20-27
pubmed: 30007202
Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18321-6
pubmed: 25489084
Lancet. 2013 Jul 20;382(9888):209-22
pubmed: 23680352
PLoS Med. 2018 Nov 6;15(11):e1002683
pubmed: 30399157
Elife. 2019 Sep 10;8:
pubmed: 31502536
ISME J. 2013 Sep;7(9):1669-77
pubmed: 23514781
mSystems. 2018 Oct 23;3(5):
pubmed: 30374458
Environ Microbiol. 2010 Jan;12(1):192-206
pubmed: 19799623
JAMA. 2017 Aug 8;318(6):517-518
pubmed: 28727867
Nat Microbiol. 2016 Aug 15;1(9):16130
pubmed: 27562262
Science. 2017 Dec 1;358(6367):1149-1154
pubmed: 29191900
Nat Med. 2016 Nov;22(11):1330-1334
pubmed: 27668938
Science. 2007 Mar 30;315(5820):1843-6
pubmed: 17395828
Science. 2018 Aug 3;361(6401):469-474
pubmed: 30072533
Mol Syst Biol. 2007;3:92
pubmed: 17353934
J Mol Biol. 2014 Nov 25;426(23):3907-16
pubmed: 24727124
ISME J. 2016 Nov;10(11):2557-2568
pubmed: 27022995
Genome Med. 2016 Apr 28;8(1):49
pubmed: 27121964
BMC Microbiol. 2014 May 01;14:112
pubmed: 24884524

Auteurs

Eric Sakowski (E)

Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Gherman Uritskiy (G)

Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA.

Rachel Cooper (R)

Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, Maryland, USA.

Maya Gomes (M)

Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, Maryland, USA.

Michael R McLaren (MR)

Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina, USA.

Jacquelyn S Meisel (JS)

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

Rebecca L Mickol (RL)

American Society for Engineering Education, Washington, DC, USA.

C David Mintz (CD)

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Emmanuel F Mongodin (EF)

University of Maryland School of Medicine, Institute for Genome Sciences, Baltimore, Maryland, USA.

Mihai Pop (M)

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

Mohammad Arifur Rahman (MA)

Department of Computer Science, George Mason University, Fairfax, Virginia, USA.

Alvaro Sanchez (A)

Department of Ecology and Evolutionary Biology, Yale University, New Haven Connecticut, USA.

Winston Timp (W)

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Jeseth Delgado Vela (JD)

Department of Civil and Environmental Engineering, Howard University, Washington, DC, USA.

Carly Muletz Wolz (CM)

Center for Conservation Genomics, Smithsonian National Zoological Park & Conservation Biology Institute, Washington, DC, USA.

Joseph P Zackular (JP)

Department of Pathology and Laboratory Medicine, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Jessica Chopyk (J)

School of Public Health, University of Maryland, College Park, Maryland, USA.

Seth Commichaux (S)

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

Meghan Davis (M)

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Douglas Dluzen (D)

Department of Biology, Morgan State University, Baltimore, Maryland, USA.

Sukirth M Ganesan (SM)

National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

Muyideen Haruna (M)

Department of Biology, Morgan State University, Baltimore, Maryland, USA.

Dan Nasko (D)

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

Mary J Regan (MJ)

University of Maryland School of Nursing, Baltimore, Maryland, USA.

Saul Sarria (S)

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

Nidhi Shah (N)

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

Brook Stacy (B)

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

Dylan Taylor (D)

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

Jocelyne DiRuggiero (J)

Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA jdiruggiero@jhu.edu sprehei1@jhu.edu.

Sarah P Preheim (SP)

Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA jdiruggiero@jhu.edu sprehei1@jhu.edu.

Classifications MeSH