Extracorporeal apheresis therapy for Alzheimer disease-targeting lipids, stress, and inflammation.


Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
02 2020
Historique:
received: 17 06 2019
accepted: 24 09 2019
revised: 13 09 2019
pubmed: 9 10 2019
medline: 15 12 2020
entrez: 10 10 2019
Statut: ppublish

Résumé

Current therapeutic approaches to Alzheimer disease (AD) remain disappointing and, hence, there is an urgent need for effective treatments. Here, we provide a perspective review on the emerging role of "metabolic inflammation" and stress as a key factor in the pathogenesis of AD and propose a novel rationale for correction of metabolic inflammation, increase resilience and potentially slow-down or halt the progression of the neurodegenerative process. Based on recent evidence and observations of an early pilot trial, we posit a potential use of extracorporeal apheresis in the prevention and treatment of AD. Apolipoprotein E, lipoprotein(a), oxidized LDL (low density lipoprotein)'s and large LDL particles, as well as other proinflammatory lipids and stress hormones such as cortisol, have been recognized as key factors in amyloid plaque formation and aggravation of AD. Extracorporeal lipoprotein apheresis systems employ well-established, powerful methods to provide an acute, reliable 60-80% reduction in the circulating concentration of these lipid classes and reduce acute cortisol levels. Following a double-membrane extracorporeal apheresis in patients with AD, there was a significant reduction of proinflammatory lipids, circulating cytokines, immune complexes, proinflammatory metals and toxic chaperones in patients with AD. On the basis of the above, we suggest designing clinical trials to assess the promising potential of such "cerebropheresis" treatment in patients with AD and, possibly, other neurodegenerative diseases.

Identifiants

pubmed: 31595035
doi: 10.1038/s41380-019-0542-x
pii: 10.1038/s41380-019-0542-x
doi:

Substances chimiques

Cholesterol, LDL 0
Lipids 0
Lipoproteins, LDL 0
oxidized low density lipoprotein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

275-282

Subventions

Organisme : Medical Research Council
ID : MC_PC_18052
Pays : United Kingdom

Références

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Auteurs

Stefan R Bornstein (SR)

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany. stefan.bornstein@ukdd.de.
Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK. stefan.bornstein@ukdd.de.
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, University Hospital, Zürich, Switzerland. stefan.bornstein@ukdd.de.

Karin Voit-Bak (K)

Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany.

Peter Rosenthal (P)

Facharzt für Nervenheilkunde, Facharzt Psychiatrie und Psychotherapie, Paulmannshöher Strasse 17, 58515, Lüdenscheid, Germany.

Sergey Tselmin (S)

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.

Ulrich Julius (U)

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.

Ulrike Schatz (U)

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.

Bernhard O Boehm (BO)

Lee Kong Chian School of Medicine, NTU Nanyang Technological University, Singapore, Singapore.

Sandrine Thuret (S)

Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Gerd Kempermann (G)

Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, 01307, Dresden, Germany.
German Center for Neurodegenerative Diseases (DZNE) Dresden, 01307, Dresden, Germany.

Heinz Reichmann (H)

Department of Neurology University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.

George P Chrousos (GP)

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.
University Research Institute of Maternal and Child Health & Precision Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Julio Licinio (J)

State University of New York Upstate Medical University, Syracuse, NY, USA.

Ma-Li Wong (ML)

State University of New York Upstate Medical University, Syracuse, NY, USA.

Andrew V Schally (AV)

Departments of Pathology, Department of Medicine, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.
Veterans Affairs Medical Center, Miami, FL, USA.

Richard Straube (R)

Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany.

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