Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours.
breast cancer
calcitriol
elderly
metastasis
ovariectomized mice
vitamin D analogues
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
02
08
2018
accepted:
21
09
2018
entrez:
10
10
2019
pubmed:
9
10
2019
medline:
9
10
2019
Statut:
epublish
Résumé
Calcitriol and its analogues are considered drugs supporting the anticancer treatment of breast cancer and preventing the osteoporosis that results from the development of cancer or from chemotherapy or hormone therapy. Following the orthotopic implantation of 4T1 mammary carcinoma cells into aged ovariectomized (OVX) mice, we evaluated the effects of calcitriol and its two analogues, PRI-2191 and PRI-2205, on metastatic spread and bone homeostasis. Calcitriol and its analogues temporarily inhibited the formation of metastases in the lungs. Unexpectedly, only mice treated with calcitriol analogues showed a deterioration of bone-related parameters, such as bone column density, marrow column density and the CaPO
Identifiants
pubmed: 31595196
doi: 10.14336/AD.2018.0921
pii: ad-10-5-977
pmc: PMC6764735
doi:
Types de publication
Journal Article
Langues
eng
Pagination
977-991Informations de copyright
Copyright: © 2019 Anisiewicz et al.
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