High Dimensional Renal Profiling: Towards a Better Understanding or Renal Transplant Immune Suppression.
belatacept
calcineurin inhibitor
high dimension profiling
immunosuppression
kidney allograft rejection
mTOR inhibitor
single cell RNA sequencing
toxicity
Journal
Current transplantation reports
ISSN: 2196-3029
Titre abrégé: Curr Transplant Rep
Pays: Switzerland
ID NLM: 101624626
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
entrez:
10
10
2019
pubmed:
9
10
2019
medline:
9
10
2019
Statut:
ppublish
Résumé
The goal of this review is to discuss new approaches to avoid CNI/CCS toxicities with a focus on new biologics and new methods to understand transplant rejection at the single-cell level. Recently developed biologics hold significant promise as the next wave of therapeutics designed to promote CNI/CCS-free long-term allograft acceptance. Indeed, belatacept, soluble CTLA4-Ig, is largely devoid of CNI-like toxicities, although it is accompanied by an increased frequency of acute rejection. Besides belatacept, other biologics hold promise as CNI-free immune suppressive approaches. Finally, powerful new single cell approaches can enable characterization of cellular populations that drive rejection within the rejecting allograft. We propose that the incorporated single cell profiling into studies investigating new biologics in transplantation, could be tailored to each patient, correlated with potential biomarkers in the blood and urine, and provide a platform where therapeutic targets can be rationally defined, mechanistically-based, and exploited.
Identifiants
pubmed: 31595214
doi: 10.1007/s40472-019-0225-1
pmc: PMC6781878
mid: NIHMS1518646
doi:
Types de publication
Journal Article
Langues
eng
Pagination
60-68Subventions
Organisme : NIAID NIH HHS
ID : R21 AI142264
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest David Hildeman reports grants from University of Cincinnati Center for Clinical & Translational Science & Training. Cyd Castro-Rojas, Steve Woodle and Rita Alloway declare no conflict of interest.
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