A phase II, open-label clinical trial on the combination therapy with medium-chain triglycerides and ghrelin in patients with chronic obstructive pulmonary disease.
Acylation
Circulation
Exercise
Muscle
Oxygen
Underweight
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
06
07
2019
accepted:
19
09
2019
pubmed:
9
10
2019
medline:
12
5
2020
entrez:
10
10
2019
Statut:
ppublish
Résumé
The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary disease (COPD). Eleven severe and very severe COPD patients received a 5-day treatment with edible MCT. Sequentially, 10 patients received a 3-week combination treatment with MCT and intravenous acyl ghrelin. Five-day MCT treatment increased endogenous acyl ghrelin (p = 0.0049), but the total ghrelin level was unchanged. MCT-ghrelin combination treatment improved the peak oxygen uptake (p = 0.0120) during whole treatment course. This effect was attributed to the resultant improvements in cardiac function by O
Identifiants
pubmed: 31595463
doi: 10.1007/s12576-019-00716-2
pii: 10.1007/s12576-019-00716-2
pmc: PMC10716959
doi:
Substances chimiques
Ghrelin
0
Triglycerides
0
Types de publication
Clinical Trial, Phase II
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
969-979Subventions
Organisme : Intramural Research Fund
ID : 25-3-1
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