Activated-cytotoxic TCRαβ+CD4+ peripheral T-cell lymphoma with hypodermal localization: Case report of a lymphoproliferative disorder probably evolved from the CD4+ cytotoxic T-cell subpopulation.
Adenocarcinoma
/ pathology
Aged
CD4-Positive T-Lymphocytes
/ immunology
Humans
Lymphoma, T-Cell, Cutaneous
/ immunology
Male
Neoplasms, Second Primary
/ pathology
Prostatic Neoplasms
/ pathology
Receptors, Antigen, T-Cell, alpha-beta
/ immunology
Skin Neoplasms
/ immunology
T-Lymphocytes, Cytotoxic
/ immunology
T lymphocytes
T-cell receptor rearrangement
cutaneous T-cell lymphoma
dermatopathology
hematopathology
Journal
Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
17
05
2018
revised:
20
09
2019
accepted:
02
10
2019
pubmed:
9
10
2019
medline:
11
11
2020
entrez:
10
10
2019
Statut:
ppublish
Résumé
The World Health Organization (WHO) classification of hematopoietic and lymphoid tumors identifies distinctive subtypes of peripheral T-cell lymphoma (PTCL), and, additionally, some PTCLs involving mostly extranodal sites like the skin. The difficulty of classifying PTCLs according to the normal stages of T-cell differentiation and the lack of definitive diagnostic markers for most of the subtypes make the diagnosis of these diseases challenging. PTCL cases which do not fit into any of the specifically defined entities are categorized as PTCL not otherwise specified (PTCL-NOS). PTCLs-NOS represent less than 2% of the total cases of T-cell lymphoma involving the skin. This article illustrates a case of a PTCL-NOS in which tumor cells have an activated cytotoxic TCRαβ+CD3+CD4+CD56+ T-cell phenotype and histopathologic features of subcutaneous panniculitis-like T-cell lymphoma, leading to a fatal outcome.
Substances chimiques
Receptors, Antigen, T-Cell, alpha-beta
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
280-285Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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