Hypoglycaemia leads to a delayed increase in platelet and coagulation activation markers in people with type 2 diabetes treated with metformin only: Results from a stepwise hypoglycaemic clamp study.
clamp
coagulation
hypoglycaemia
hypoglycaemic clamp
metformin
platelet activation
type 2 diabetes
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
02
05
2019
revised:
11
09
2019
accepted:
27
09
2019
pubmed:
9
10
2019
medline:
7
4
2021
entrez:
10
10
2019
Statut:
ppublish
Résumé
To investigate the effect of hypoglycaemia on platelet and coagulation activation in people with type 2 diabetes. This monocentric, open, single-arm, mechanistic trial included 14 people with established type 2 diabetes (four women, 10 men, age 55 ± 7 years, glycated haemoglobin concentration 51 ± 7 mmol/mol) receiving metformin monotherapy. A stepwise hyperinsulinaemic-hypoglycaemic clamp experiment (3.5 and 2.5 mmol/L, for 30 minutes respectively) was performed, aiming to investigate platelet and coagulation activity during predefined plateaus of hypoglycaemia, as well as 1 day and 7 days later. While platelet activation assessed by light transmittance aggregometry did not significantly increase after the hypoglycaemic clamp procedure, the more sensitive flow cytometry-based measurement of platelet surface activation markers showed hypoglycaemia-induced activation 24 hours (PAC1 A single event of insulin-induced hypoglycaemia led to an increase in markers of platelet activation and coagulation in people with early stages of type 2 diabetes on metformin therapy. However, the activation occurred with a delay and was evident 24 hours and 7 days after the actual hypoglycaemic episode.
Identifiants
pubmed: 31595635
doi: 10.1111/dom.13889
pmc: PMC6972619
doi:
Substances chimiques
Biomarkers
0
Metformin
9100L32L2N
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
212-221Subventions
Organisme : Investigator Initiated Studies Program of Merck Sharp & Dohme Corp
Pays : International
Informations de copyright
© 2019 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
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