B cell reconstitution following alemtuzumab induction under a belatacept-based maintenance regimen.
B cell biology
basic (laboratory) research/science
clinical research/practice
costimulation
immunosuppression/immune modulation
immunosuppressive regimens - induction
lymphocyte biology: differentiation/maturation
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
23
01
2019
revised:
06
09
2019
accepted:
24
09
2019
pubmed:
10
10
2019
medline:
22
6
2021
entrez:
10
10
2019
Statut:
ppublish
Résumé
Lymphocyte depletion has been shown to control costimulation blockade-resistant rejection but, in some settings, to exacerbate antibody-mediated rejection (AMR). We have used alemtuzumab, which depletes T and B cells, combined with belatacept and rapamycin and previously reported control of both costimulation blockade-resistant rejection and AMR. To evaluate this regimen's effect on B cell signatures, we investigated 40 patients undergoing this therapy. B cell counts and phenotypes were interrogated using flow cytometry, and serum was analyzed for total IgG, IgM, and donor-specific alloantibody (DSA). Alemtuzumab induction produced pan-lymphocyte depletion; B cells repopulated faster and more completely than T cells. Reconstituting B cells were predominantly naïve, and memory B cells were significantly reduced (P = .001) post repopulation. Two B cell populations with potential immunomodulatory effects-regulatory (CD38
Identifiants
pubmed: 31596034
doi: 10.1111/ajt.15639
pmc: PMC7202689
mid: NIHMS1571731
pii: S1600-6135(22)22230-8
doi:
Substances chimiques
Alemtuzumab
3A189DH42V
Abatacept
7D0YB67S97
Banques de données
ClinicalTrials.gov
['NCT00565773']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
653-662Subventions
Organisme : FDA HHS
ID : R01 FD003539
Pays : United States
Organisme : Roche Organ Transplant Research Foundation
ID : 346678023
Pays : International
Organisme : NIH HHS
ID : R01 AI097423
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI097423
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002553
Pays : United States
Organisme : United States Food and Drug Administration
ID : 1R01 FD003539-01
Pays : International
Informations de copyright
© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.
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