Magnetically Actuated SiCN-Based Ceramic Microrobot for Guided Cell Delivery.
biocompatible materials
cell delivery
ceramic microrobots
magnetic nanoparticles
silicon carbonitride
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
09
06
2019
revised:
18
09
2019
pubmed:
10
10
2019
medline:
1
9
2020
entrez:
10
10
2019
Statut:
ppublish
Résumé
A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface-modified ceramic carrier by thiol-ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells.
Identifiants
pubmed: 31596550
doi: 10.1002/adhm.201900739
doi:
Substances chimiques
Biocompatible Materials
0
Polymers
0
Silicon Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900739Subventions
Organisme : National Research Foundation of Korea
ID : 2017R1A3B1023598
Pays : International
Organisme : Ministry of Science and ICT
ID : 19-CoE-BT-02
Pays : International
Organisme : National Research Foundation
Pays : International
Organisme : Korean government (MSIP)
ID : NRF-2017R1A3B1023598
Pays : International
Organisme : Korean government (MSIP)
ID : NRF-2016R1A2-B4008473
Pays : International
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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