Protective Effects of Melatonin on the Skin: Future Perspectives.
aging
melatonin
mitochondria
oxidative stress
skin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Oct 2019
08 Oct 2019
Historique:
received:
16
09
2019
revised:
30
09
2019
accepted:
07
10
2019
entrez:
11
10
2019
pubmed:
11
10
2019
medline:
18
2
2020
Statut:
epublish
Résumé
When exposed to hostile environments such as radiation, physical injuries, chemicals, pollution, and microorganisms, the skin requires protective chemical molecules and pathways. Melatonin, a highly conserved ancient molecule, plays a crucial role in the maintenance of skin. As human skin has functional melatonin receptors and also acts as a complete system that is capable of producing and regulating melatonin synthesis, melatonin is a promising candidate for its maintenance and protection. Below, we review the studies of new metabolic pathways involved in the protective functions of melatonin in dermal cells. We also discuss the advantages of the topical use of melatonin for therapeutic purposes and skin protection. In our view, endogenous intracutaneous melatonin production, together with topically-applied exogenous melatonin and its metabolites, represent two of the most potent defense systems against external damage to the skin.
Identifiants
pubmed: 31597233
pii: ijms20194948
doi: 10.3390/ijms20194948
pmc: PMC6802208
pii:
doi:
Substances chimiques
Antioxidants
0
Protective Agents
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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