Orthopedia Homeobox (OTP) in Pulmonary Neuroendocrine Tumors: The Diagnostic Value and Possible Molecular Interactions.
classification
neuroendocrine tumor
orthopedia homeobox
prognosis
pulmonary carcinoid
review
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Oct 2019
08 Oct 2019
Historique:
received:
20
08
2019
revised:
06
09
2019
accepted:
09
09
2019
entrez:
11
10
2019
pubmed:
11
10
2019
medline:
11
10
2019
Statut:
epublish
Résumé
Generally, patients with stage I-IIIa (TNM) pulmonary carcinoid disease have a favourable prognosis after curative resection. Yet, distant recurrence of disease after curative surgery occurs in approximately 1-6% of patients with typical carcinoid and 14-29% in patients with atypical carcinoid disease, respectively. Known predictors of distant recurrence of disease are atypical carcinoid, lymphatic involvement, and incomplete resection status. However, none of them can be reliably used, alone or in combination, to exclude patients from long-term follow-up (advised 15 years). By genomic profiling, Orthopedia homeobox (
Identifiants
pubmed: 31597385
pii: cancers11101508
doi: 10.3390/cancers11101508
pmc: PMC6826717
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : KWF Kankerbestrijding
ID : 10956
Déclaration de conflit d'intérêts
Laura Moonen, Jules Derks, and Ernst-Jan Speel declare no conflict of interest. Anne-Marie Dingemans reports grants and personal fees from BMS, personal fees from Roche, personal fees from MSD, personal fees from Eli Lily, personal fees from Takeda, personal fees from Pfizer, personal fees from Boehringer Ingelheim, outside the submitted work.The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results”.
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