Diabetic ketoacidosis at the onset of disease during a national awareness campaign: a 2-year observational study in children aged 0-18 years.
diabetes
diabetic ketoacidosis
epidemiology
Journal
Archives of disease in childhood
ISSN: 1468-2044
Titre abrégé: Arch Dis Child
Pays: England
ID NLM: 0372434
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
23
01
2019
revised:
11
09
2019
accepted:
21
09
2019
pubmed:
11
10
2019
medline:
28
7
2020
entrez:
11
10
2019
Statut:
ppublish
Résumé
After a previous survey on the incidence of diabetic ketoacidosis (DKA) at onset of type 1 diabetes in children in 2013-2014 in Italy, we aimed to verify a possible decline in the incidence of DKA at onset during a national prevention campaign. Prospective observational study. Multicentre study throughout Italy. National awareness campaign started in November 2015 and held until December 2017. During 2016 and 2017 we collected data on all patients aged 0-18 years with new-onset diabetes. DKA (pH <7.30), severe DKA (pH <7.1), DKA in children below 6 years and DKA treatment according to the Italian Society for Pediatric Endocrinology and Diabetology (ISPED) protocol were evaluated. Records (n=2361) of children with newly diagnosed type 1 diabetes were collected from 58 out of 68 (85.3%) centres of the original survey participants and 100% of the previously surveyed tertiary centres. Overall, DKA was observed in 1124 patients, with an increased rate when compared with the previous survey (47.6% vs 38.5%, p=0.002), and severe DKA in 15.3%. In children below 6 years, DKA was observed in 323 out of 617 (52.5%) and severe DKA in 16.7%; in this age group, occurrence of DKA reduced by 21.3% (p=0.009). DKA treatment according to the ISPED guidelines was adopted in 95% of the centres, with a 27% improvement (p=0.025). During a 2-year awareness campaign, DKA at onset of diabetes in children and adolescents 0-18 years is still common and increased when compared with the 2013-2014 survey.
Identifiants
pubmed: 31597646
pii: archdischild-2019-316903
doi: 10.1136/archdischild-2019-316903
doi:
Substances chimiques
Blood Glucose
0
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-366Investigateurs
R Lera
(R)
V Cherubini
(V)
A Bobbio
(A)
E Piccinno
(E)
S Zucchini
(S)
G Maltoni
(G)
P Reinstadler
(P)
B Felappi
(B)
E Prandi
(E)
F Gallo
(F)
A P Frongia
(AP)
C Ripoli
(C)
D Lo Presti
(D)
L Tomaselli
(L)
G Cardinale
(G)
F A Stamati
(FA)
F Citriniti
(F)
T Suprani
(T)
V Graziani
(V)
F De Berardinis
(F)
M Zampolli
(M)
R De Marco
(R)
A Scaramuzza
(A)
C Cavalli
(C)
N Lazzaro
(N)
V De Donno
(V)
S Toni
(S)
B Piccini
(B)
L Lenzi
(L)
B Mainetti
(B)
M S Coccioli
(MS)
None d'Annunzio
N Minuto
(N)
S Aloe
(S)
D Lucchesi
(D)
S Cirillo
(S)
M Sordelli
(M)
M Delvecchio
(M)
G Salzano
(G)
R Bonfanti
(R)
F Meschi
(F)
L Iughetti
(L)
B Predieri
(B)
A Franzese
(A)
E Mozzillo
(E)
D Iafusco
(D)
F Cadario
(F)
S Savastio
(S)
G Piredda
(G)
F Cardella
(F)
B Iovane
(B)
V Calcaterra
(V)
M G Berioli
(MG)
M Biagioni
(M)
E Randazzo
(E)
I Patera
(I)
R Schiaffini
(R)
I Rutigliano
(I)
A Lasagni
(A)
S Innaurato
(S)
A Gaiero
(A)
G Fichera
(G)
I Rabbone
(I)
D Tinti
(D)
M Trada
(M)
L Guerraggio
(L)
V Cauvin
(V)
R Franceschi
(R)
G Tornese
(G)
A Salvatoni
(A)
M Marigliano
(M)
A Sabbion
(A)
C Maffeis
(C)
C Arnaldi
(C)
F Lombardo
(F)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.