A Common Live-Attenuated Avian Herpesvirus Vaccine Expresses a Very Potent Oncogene.
CVI988/Rispens
Marek’s disease virus (MDV)
T cell lymphoma
basic leucine zipper (bZIP) protein
cancer
herpesvirus telomerase RNA (vTR)
meq gene
tumorigenesis
vaccine
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
09 10 2019
09 10 2019
Historique:
entrez:
11
10
2019
pubmed:
11
10
2019
medline:
27
2
2020
Statut:
epublish
Résumé
Vaccines play a crucial role in the protection of animals and humans from deadly pathogens. The first vaccine that also protected against cancer was developed against the highly oncogenic herpesvirus Marek's disease virus (MDV). MDV infects chickens and causes severe immunosuppression, neurological signs, and fatal lymphomas, a process that requires the viral oncogene,
Identifiants
pubmed: 31597721
pii: 4/5/e00658-19
doi: 10.1128/mSphere.00658-19
pmc: PMC6796977
pii:
doi:
Substances chimiques
Eco-Q protein, Gallid herpesvirus 2
0
Marek Disease Vaccines
0
Oncogene Proteins, Viral
0
Vaccines, Attenuated
0
Vaccines, Synthetic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 Conradie et al.
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