Noninvasive Detection of Antibodies to Human T-Cell Lymphotropic Virus Types 1 and 2 by Use of Oral Fluid.


Journal

Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564

Informations de publication

Date de publication:
12 2019
Historique:
received: 19 07 2019
accepted: 30 09 2019
pubmed: 11 10 2019
medline: 17 7 2020
entrez: 11 10 2019
Statut: epublish

Résumé

Human T-lymphotropic viruses type 1 and 2 (HTLV-1/2) are prevalent in endemic clusters globally, and HTLV-1 infects at least 5 to 10 million individuals. Infection can lead to inflammation in the spinal cord, resulting in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), or adult T cell leukemia/lymphoma (ATL). Obtaining venous blood for serological screening, typically performed using enzyme immunoassays (EIAs), is invasive, sometimes socially unacceptable, and has restricted large-scale seroprevalence studies. Collecting oral fluid (OF) is a noninvasive alternative to venesection. In this study, an IgG antibody capture EIA was developed and validated to detect anti-HTLV-1/2 IgG in OF. OF and plasma specimens were obtained from seropositive HTLV-1/2-infected patients attending the National Centre for Human Retrovirology (

Identifiants

pubmed: 31597746
pii: JCM.01179-19
doi: 10.1128/JCM.01179-19
pmc: PMC6879298
pii:
doi:

Substances chimiques

Antibodies, Viral 0
Immunoglobulin G 0

Types de publication

Evaluation Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 American Society for Microbiology.

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Auteurs

Timothy Woo (T)

Department of Infectious Disease, Imperial College London, London, United Kingdom.

Carolina Rosadas (C)

Department of Infectious Disease, Imperial College London, London, United Kingdom.

Samreen Ijaz (S)

Blood Borne Virus Unit, Virus Reference Department, Public Health England, London, United Kingdom.

Steve Dicks (S)

Blood Borne Virus Unit, Virus Reference Department, Public Health England, London, United Kingdom.

Jennifer H C Tosswill (JHC)

Blood Borne Virus Unit, Virus Reference Department, Public Health England, London, United Kingdom.

Richard S Tedder (RS)

Department of Infectious Disease, Imperial College London, London, United Kingdom.
Blood Borne Virus Unit, Virus Reference Department, Public Health England, London, United Kingdom.

Graham P Taylor (GP)

Department of Infectious Disease, Imperial College London, London, United Kingdom g.p.taylor@imperial.ac.uk.

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Classifications MeSH