Herpes Simplex Virus 1 Induces Brain Inflammation and Multifocal Demyelination in the Cotton Rat Sigmodon hispidus.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
12 12 2019
Historique:
received: 12 07 2019
accepted: 30 09 2019
pubmed: 11 10 2019
medline: 12 6 2020
entrez: 11 10 2019
Statut: epublish

Résumé

Demyelinating central nervous system (CNS) disorders like multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM) have been difficult to study and treat due to the lack of understanding of their etiology. Numerous cases point to the link between herpes simplex virus (HSV) infection and multifocal CNS demyelination in humans; however, convincing evidence from animal models has been missing. In this work, we found that HSV-1 infection of the cotton rat

Identifiants

pubmed: 31597775
pii: JVI.01161-19
doi: 10.1128/JVI.01161-19
pmc: PMC6912097
pii:
doi:

Substances chimiques

Herpes Simplex Virus Vaccines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 Boukhvalova et al.

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Auteurs

Marina S Boukhvalova (MS)

Sigmovir Biosystems, Inc., Rockville, Maryland, USA m.boukhvalova@sigmovir.com.

Emma Mortensen (E)

Sigmovir Biosystems, Inc., Rockville, Maryland, USA.

Aissatou Mbaye (A)

Sigmovir Biosystems, Inc., Rockville, Maryland, USA.

Diego Lopez (D)

Sigmovir Biosystems, Inc., Rockville, Maryland, USA.

Lorne Kastrukoff (L)

The University of British Columbia, Department of Medicine, Vancouver, BC, Canada.

Jorge C G Blanco (JCG)

Sigmovir Biosystems, Inc., Rockville, Maryland, USA.

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