High dynamic range fluorescence imaging.
Intravital microscopy
drug imaging
high dynamic range
in vivo imaging
optical imaging
Journal
IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
ISSN: 1077-260X
Titre abrégé: IEEE J Sel Top Quantum Electron
Pays: United States
ID NLM: 101212349
Informations de publication
Date de publication:
Historique:
entrez:
11
10
2019
pubmed:
11
10
2019
medline:
11
10
2019
Statut:
ppublish
Résumé
Fluorescence acquisition and image display over a high dynamic range is highly desirable. However, the limited dynamic range of current photodetectors and imaging CCDs impose a limit on the fluorescence intensities that can be simultaneously captured during a single image acquisition. This is particularly troublesome when imaging biological samples, where protein expression fluctuates considerably. As a result, biological images will often contain regions with signal that is either saturated or hidden within background noise, causing information loss. In this manuscript we summarize recent work from our group and others, to extended conventional to high dynamic range fluorescence imaging. These strategies have many biological applications, such as mapping of neural connections, vascular imaging, bio-distribution studies or pharmacologic imaging at the single cell and organ level.
Identifiants
pubmed: 31598059
doi: 10.1109/JSTQE.2018.2881608
pmc: PMC6785194
mid: NIHMS1516374
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R01 CA206890
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122208
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131495
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA206997
Pays : United States
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