Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery.
Cycloaddition
Diversity‐oriented synthesis
Fragment‐based drug discovery
Heterocycles
Spirocycles
Journal
European journal of organic chemistry
ISSN: 1434-193X
Titre abrégé: European J Org Chem
Pays: Germany
ID NLM: 9805750
Informations de publication
Date de publication:
01 Sep 2019
01 Sep 2019
Historique:
received:
13
06
2019
entrez:
11
10
2019
pubmed:
11
10
2019
medline:
11
10
2019
Statut:
ppublish
Résumé
In recent years the pharmaceutical industry has benefited from the advances made in fragment-based drug discovery (FBDD) with more than 30 fragment-derived drugs currently marketed or progressing through clinical trials. The success of fragment-based drug discovery is entirely dependent upon the composition of the fragment screening libraries used. Heterocycles are prevalent within marketed drugs due to the role they play in providing binding interactions; consequently, heterocyclic fragments are important components of FBDD libraries. Current screening libraries are dominated by flat, sp
Identifiants
pubmed: 31598091
doi: 10.1002/ejoc.201900847
pii: EJOC201900847
pmc: PMC6774287
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5219-5229Informations de copyright
© 2019 The Authors. Published by Wiley‐VCH Verlag GmbH & Co. KGaA.
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