α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
02
08
2019
accepted:
26
08
2019
pubmed:
11
10
2019
medline:
8
9
2020
entrez:
11
10
2019
Statut:
ppublish
Résumé
We applied RT-QuIC assay to detect α-synuclein aggregates in cerebrospinal fluid (CSF) of patients with suspected Creutzfeldt-Jakob disease who had a neuropathological diagnosis of dementia with Lewy bodies (DLB) (n = 7), other neurodegenerative diseases with α-synuclein mixed pathology (n = 20), or without Lewy-related pathology (n = 49). The test had a sensitivity of 92.9% and specificity of 95.9% in distinguishing α-synucleinopathies from non-α-synucleinopathies. When performed in the CSF of patients with DLB (n = 36), RT-QuIC was positive in 17/20 with probable DLB, 0/6 with possible DLB, and 0/10 with Alzheimer disease. These results indicate that RT-QuIC for α-synuclein is an accurate test for DLB diagnosis.
Identifiants
pubmed: 31599499
doi: 10.1002/acn3.50897
pmc: PMC6801172
doi:
Substances chimiques
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2120-2126Subventions
Organisme : NIA NIH HHS
ID : P30 AG010133
Pays : United States
Organisme : Veneto Region
ID : RP-2014-00000400
Pays : International
Organisme : Ministero della Salute, Italy
ID : RF-2013-02354884 and GR-2013-02355724
Pays : International
Informations de copyright
© 2019 University of Verona. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.
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