Ecological association between residential natural background radiation exposure and the incidence rate of childhood central nervous system tumors in France, 2000-2012.
Central nervous system tumors
Childhood cancer
Ecological study
Natural background radiation
Radon
Journal
Journal of environmental radioactivity
ISSN: 1879-1700
Titre abrégé: J Environ Radioact
Pays: England
ID NLM: 8508119
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
30
04
2019
revised:
01
08
2019
accepted:
23
09
2019
pubmed:
11
10
2019
medline:
19
3
2020
entrez:
11
10
2019
Statut:
ppublish
Résumé
High-dose ionizing radiation is an established risk factor for childhood central nervous system tumors (CNST) but the role of low doses remains debated. In particular, there are few studies of natural background radiation (NBR, gamma radiation and radon) and childhood CNST, and their results are inconclusive. This study aimed to investigate the ecological association between NBR exposure and childhood CNST incidence in France, considering childhood CNST overall and by subgroups. Incidence data were provided by the French national registry of childhood cancers, which has high completeness. We included 5471 childhood CNST cases registered over the period 2000-2012, and their municipality of residence at diagnosis was recorded. Municipality NBR exposures were estimated by cokriging models, using NBR measurements and additional geographic data. The incidence rate ratio (IRR) per unit variation of exposure was estimated with Poisson regression models. NBR exposures were considered at the time of diagnosis, and cumulatively from birth to diagnosis. In an exploratory analysis, the total brain dose due to NBR was used. Overall, there was no association between NBR exposure and childhood CNST incidence (IRR = 1.03 (0.98,1.09) per 50 nSv/h for gamma radiation, and IRR = 1.02 (0,96,1.07) per 100 Bq/m Our study was based on high quality incidence data, large numbers of CNST cases, and validated models of NBR exposure assessment. Results suggest an association between gamma radiation, as a component of NBR, and pilocytic astrocytomas incidence in France.
Sections du résumé
BACKGROUND
BACKGROUND
High-dose ionizing radiation is an established risk factor for childhood central nervous system tumors (CNST) but the role of low doses remains debated. In particular, there are few studies of natural background radiation (NBR, gamma radiation and radon) and childhood CNST, and their results are inconclusive.
OBJECTIVES
OBJECTIVE
This study aimed to investigate the ecological association between NBR exposure and childhood CNST incidence in France, considering childhood CNST overall and by subgroups.
METHODS
METHODS
Incidence data were provided by the French national registry of childhood cancers, which has high completeness. We included 5471 childhood CNST cases registered over the period 2000-2012, and their municipality of residence at diagnosis was recorded. Municipality NBR exposures were estimated by cokriging models, using NBR measurements and additional geographic data. The incidence rate ratio (IRR) per unit variation of exposure was estimated with Poisson regression models. NBR exposures were considered at the time of diagnosis, and cumulatively from birth to diagnosis. In an exploratory analysis, the total brain dose due to NBR was used.
RESULTS
RESULTS
Overall, there was no association between NBR exposure and childhood CNST incidence (IRR = 1.03 (0.98,1.09) per 50 nSv/h for gamma radiation, and IRR = 1.02 (0,96,1.07) per 100 Bq/m
CONCLUSIONS
CONCLUSIONS
Our study was based on high quality incidence data, large numbers of CNST cases, and validated models of NBR exposure assessment. Results suggest an association between gamma radiation, as a component of NBR, and pilocytic astrocytomas incidence in France.
Identifiants
pubmed: 31600676
pii: S0265-931X(19)30348-0
doi: 10.1016/j.jenvrad.2019.106071
pii:
doi:
Substances chimiques
Radon
Q74S4N8N1G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106071Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.