Phlorotannins from
Animals
Cell Line
Diet, High-Fat
/ adverse effects
Endoplasmic Reticulum Stress
/ drug effects
Humans
Hypothalamus
/ drug effects
Leptin
/ metabolism
Mice
Microglia
/ drug effects
NF-kappa B
/ metabolism
Neurons
/ drug effects
Obesity
/ metabolism
Palmitates
/ pharmacology
Phaeophyceae
/ chemistry
Phloroglucinol
/ pharmacology
Prohibitins
Receptors, Leptin
/ metabolism
STAT3 Transcription Factor
/ metabolism
Signal Transduction
/ drug effects
Tannins
/ pharmacology
Toll-Like Receptor 4
/ metabolism
Ecklonia cava
endoplasmic reticulum stress
hypothalamic neurons
leptin resistance
microglia
obesity
phlorotannins
toll-like receptor 4
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
09 Oct 2019
09 Oct 2019
Historique:
received:
02
09
2019
revised:
30
09
2019
accepted:
08
10
2019
entrez:
12
10
2019
pubmed:
12
10
2019
medline:
28
2
2020
Statut:
epublish
Résumé
Leptin resistance in the hypothalamus has an essential role in obesity. Saturated fatty acids such as palmitate bind to Toll-like receptor 4 (TLR4) and lead to endoplasmic reticulum (ER) stress and leptin resistance. In this study, we evaluated whether extracts of
Identifiants
pubmed: 31600939
pii: md17100570
doi: 10.3390/md17100570
pmc: PMC6835517
pii:
doi:
Substances chimiques
Leptin
0
NF-kappa B
0
PHB protein, human
0
Palmitates
0
Prohibitins
0
Receptors, Leptin
0
STAT3 Transcription Factor
0
Tannins
0
Toll-Like Receptor 4
0
Phloroglucinol
DHD7FFG6YS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of SMEs and Startups
ID : P0002990
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