Association between chlorhexidine gluconate concentrations and resistant bacterial bioburden on skin.

Anti-Infective Agents, Local / administration & dosage Chlorhexidine / administration & dosage Dose-Response Relationship, Drug Drug Resistance, Bacterial Humans Skin / microbiology

Journal

Infection control and hospital epidemiology
ISSN: 1559-6834
Titre abrégé: Infect Control Hosp Epidemiol
Pays: United States
ID NLM: 8804099

Informations de publication

Date de publication:
12 2019
Historique:
pubmed: 12 10 2019
medline: 2 6 2020
entrez: 12 10 2019
Statut: ppublish

Résumé

We studied the association between chlorhexidine gluconate (CHG) concentration on skin and resistant bacterial bioburden. CHG was almost always detected on the skin, and detection of methicillin-resistant Staphylococcus aureus, carbapenem-resistant Enterobacteriaceae, and vancomycin-resistant Enterococcus on skin sites was infrequent. However, we found no correlation between CHG concentration and bacterial bioburden.

Identifiants

DOI: 10.1017/ice.2019.265 PMID: 31601280 PMC: PMC6897301
pubmed: 31601280
pii: S0899823X19002654
doi: 10.1017/ice.2019.265
pmc: PMC6897301
mid: NIHMS1060930
doi:

Substances chimiques

Anti-Infective Agents, Local 0
chlorhexidine gluconate MOR84MUD8E
Chlorhexidine R4KO0DY52L

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1430-1432

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI121146
Pays : United States
Organisme : NCEZID CDC HHS
ID : U54 CK000450
Pays : United States
Organisme : ACL HHS
ID : U54CK000450
Pays : United States

Références

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pubmed: 27428384
Infect Control Hosp Epidemiol. 2012 Mar;33(3):257-67
pubmed: 22314063
Clin Infect Dis. 2008 Jan 15;46(2):274-81
pubmed: 18171263
J Am Coll Surg. 2008 Aug;207(2):233-9
pubmed: 18656052
Crit Care Med. 2012 Apr;40(4):1333-4
pubmed: 22425825
Arch Intern Med. 2006 Feb 13;166(3):306-12
pubmed: 16476870
Infect Control Hosp Epidemiol. 2015 Sep;36(9):1095-7
pubmed: 26074153
Am J Infect Control. 2018 Feb;46(2):226-228
pubmed: 28993110
Am J Infect Control. 2016 May 2;44(5 Suppl):e17-21
pubmed: 27131130
Infect Control Hosp Epidemiol. 2012 Sep;33(9):889-96
pubmed: 22869262

Auteurs

Gita Nadimpalli (G)

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
ORCID: 0000-0002-6283-1032

Lyndsay M O'Hara (LM)

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

Surbhi Leekha (S)

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

David P Calfee (DP)

Division of Infectious Diseases, Weill Cornell Medicine, New York, New York.

Loren G Miller (LG)

LA Biomedical Research Center at Harbor-UCLA Medical Center, Torrance, California.

Lisa Pineles (L)

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

Natalia Blanco (N)

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
ORCID: 0000-0002-3157-1119

J Kristie Johnson (JK)

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.

Anthony D Harris (AD)

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Anti-infectieux locaux › Association between chlorhexidine gluconate...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Biguanides › Chlorhexidine › Association between chlorhexidine gluconate...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Association between chlorhexidine gluconate...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Association between chlorhexidine gluconate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association between chlorhexidine gluconate...
questionsmedicales.fr › Système tégumentaire › Peau › Association between chlorhexidine gluconate...