Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1.
Animals
Chitin
/ metabolism
DNA, Ribosomal Spacer
Disease Models, Animal
Enteritis
/ etiology
Fungi
/ physiology
Gastrointestinal Microbiome
Gene Expression
Humans
Intestinal Mucosa
/ metabolism
Metagenomics
Mice
Mice, Transgenic
Microbial Interactions
Mycobiome
Protein Binding
RNA, Ribosomal, 16S
Receptors, Cell Surface
/ metabolism
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
02 12 2019
02 12 2019
Historique:
received:
05
12
2018
revised:
29
06
2019
accepted:
10
09
2019
pubmed:
12
10
2019
medline:
17
6
2020
entrez:
12
10
2019
Statut:
ppublish
Résumé
Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.
Identifiants
pubmed: 31601676
pii: jem.20182244
doi: 10.1084/jem.20182244
pmc: PMC6888979
doi:
Substances chimiques
DNA, Ribosomal Spacer
0
RNA, Ribosomal, 16S
0
Receptors, Cell Surface
0
Chitin
1398-61-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2689-2700Subventions
Organisme : NIAID NIH HHS
ID : R01 AI074878
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI095466
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI095608
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI137157
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113136
Pays : United States
Organisme : NIAID NIH HHS
ID : F32 AI124517
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI102942
Pays : United States
Informations de copyright
© 2019 Moeller et al.
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