SPIONs/3D SiSBA-16 based Multifunctional Nanoformulation for target specific cisplatin release in colon and cervical cancer cell lines.
Adsorption
Antineoplastic Agents
/ administration & dosage
Apoptosis
Cell Line, Tumor
Cisplatin
/ administration & dosage
Colonic Neoplasms
/ drug therapy
Drug Carriers
Female
HCT116 Cells
HEK293 Cells
HeLa Cells
Humans
Kidney
/ drug effects
Magnetic Resonance Imaging
Magnetite Nanoparticles
/ chemistry
Microscopy, Electron, Transmission
Silicon Dioxide
/ chemistry
Uterine Cervical Neoplasms
/ drug therapy
X-Ray Diffraction
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 10 2019
10 10 2019
Historique:
received:
25
10
2018
accepted:
19
09
2019
entrez:
12
10
2019
pubmed:
12
10
2019
medline:
12
11
2020
Statut:
epublish
Résumé
Multifunctional nanomaterials can be used for dual applications: drug delivery as well as in bioimaging. In current study, we investigated potential use of silica based supports; 3D cage type SiSBA-16 (S-16), monodispersed hydrophilic spherical silica (HYPS) and mesocellular foam (MSU-F) for cisplatin (Cp) delivery. To obtain magnetic resonance characteristics, 10 wt% iron oxide was loaded through enforced adsorption technique. For pH stimuli responsive release of Cp, 10 wt%SPIONs/S-16 was functionalized with 3-(Aminopropyl)triethoxysilane (A) and poly acrylic acid (PAA) termed as 10 wt%SPIONs/S-16-A-Cp and 10 wt%SPIONs/S-16-APAA-Cp. By TEM analysis, the average diameter of the SPIONs was found to range between 10-60 nm. VSM analysis showed saturation magnetization over S-16, HYPS and MSU-F were in the following order: 10 wt%SPIONs/HYPS (4.08 emug
Identifiants
pubmed: 31601952
doi: 10.1038/s41598-019-51051-w
pii: 10.1038/s41598-019-51051-w
pmc: PMC6787005
doi:
Substances chimiques
Antineoplastic Agents
0
Drug Carriers
0
Magnetite Nanoparticles
0
Silicon Dioxide
7631-86-9
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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