Influence of the Body Mass Index and its Effect on Tumor Characteristics and Survival among a Population with Access to Surgical Management of Upper Tract Urothelial Carcinoma.
Body mass index
Prognosis
Upper tract urothelial carcinoma
Journal
Current urology
ISSN: 1661-7649
Titre abrégé: Curr Urol
Pays: United States
ID NLM: 101471188
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
26
03
2018
accepted:
29
06
2018
entrez:
12
10
2019
pubmed:
12
10
2019
medline:
12
10
2019
Statut:
ppublish
Résumé
To examine the association between the body mass index (BMI) and the risk of survival, and to evaluate whether tumor characteristics differ by BMI in patients with upper tract urothelial carcinoma (UTUC) managed by surgery. A clinical series on 876 patients with localized UTUC following nephroureterectomy with a bladder cuff, with data from Osaka Medical College registry (discovery cohort) and the Nagoya group (validation cohort) was examined. In addition to analyzing the overall survival and cancer-specific survival (CSS), the survival impact adjusted by pathological variables was also assessed by the BMI group. The percentage of high risk features including positive lymphovascular invasion was doubled in the discovery cohort compared to the validation cohort. The group of BMI ≥ 25 kg/m We found a clinically relevant signature for high risk patients with BMI grouping. Further research is necessary on whether tailoring recommendations for weight and nutrition management to tumor characteristics will improve outcomes.
Identifiants
pubmed: 31602186
doi: 10.1159/000499305
pii: cur-0012-0201
pmc: PMC6738144
doi:
Types de publication
Journal Article
Langues
eng
Pagination
201-209Informations de copyright
Copyright © 2019 by S. Karger AG, Basel.
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