Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans.

Animals Animals, Genetically Modified Caenorhabditis elegans / embryology Caenorhabditis elegans Proteins / genetics DNA-Binding Proteins / genetics Embryo, Nonmammalian Histone-Lysine N-Methyltransferase / metabolism Multiprotein Complexes / metabolism Protein Binding Sin3 Histone Deacetylase and Corepressor Complex / metabolism Trans-Activators / metabolism

Journal

Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011

Informations de publication

Date de publication:
02 12 2019
Historique:
accepted: 07 10 2019
revised: 13 09 2019
received: 01 03 2019
pubmed: 12 10 2019
medline: 2 6 2020
entrez: 12 10 2019
Statut: ppublish

Résumé

The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin factors contribute to context dependent effects. Using a proteomics approach, we identified CFP1 associated proteins and an unexpected direct link between Caenorhabditis elegans CFP-1 and an Rpd3/Sin3 small (SIN3S) histone deacetylase complex. Supporting a functional connection, we find that mutants of COMPASS and SIN3 complex components genetically interact and have similar phenotypic defects including misregulation of common genes. CFP-1 directly binds SIN-3 through a region including the conserved PAH1 domain and recruits SIN-3 and the HDA-1/HDAC subunit to H3K4me3 enriched promoters. Our results reveal a novel role for CFP-1 in mediating interaction between SET1/COMPASS and a Sin3S HDAC complex at promoters.

Identifiants

DOI: 10.1093/nar/gkz880 PMID: 31602465 PMC: PMC6868398
pubmed: 31602465
pii: 5585547
doi: 10.1093/nar/gkz880
pmc: PMC6868398
doi:

Substances chimiques

Caenorhabditis elegans Proteins 0
DNA-Binding Proteins 0
Multiprotein Complexes 0
Trans-Activators 0
cfp-1 protein, C elegans 0
Histone-Lysine N-Methyltransferase EC 2.1.1.43
Set-1 protein, C elegans EC 2.1.1.43
Sin3 Histone Deacetylase and Corepressor Complex EC 3.5.1.98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11164-11180

Subventions

Organisme : Wellcome Trust
ID : 092096
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C6946/A14492
Pays : United Kingdom

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

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Auteurs

Flore Beurton (F)

Laboratory of Biology and Modeling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France.

Przemyslaw Stempor (P)

The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.

Matthieu Caron (M)

Laboratory of Biology and Modeling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France.

Alex Appert (A)

The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.

Yan Dong (Y)

The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.

Ron A-J Chen (RA)

The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.

David Cluet (D)

Laboratory of Biology and Modeling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France.

Yohann Couté (Y)

Grenoble Alpes, CEA, Inserm, BIG-BGE, 38000 Grenoble, France.

Marion Herbette (M)

Laboratory of Biology and Modeling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France.

Ni Huang (N)

The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.

Hélène Polveche (H)

INSERM UMR 861, I-STEM, 28, Rue Henri Desbruères, 91100 Corbeil-Essonnes, France.

Martin Spichty (M)

Laboratory of Biology and Modeling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France.

Cécile Bedet (C)

Laboratory of Biology and Modeling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France.

Julie Ahringer (J)

The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.

Francesca Palladino (F)

Laboratory of Biology and Modeling of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, Université de Lyon, Lyon, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Physical and functional interaction between...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Physical and functional interaction between...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Physical and functional interaction between...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › Physical and functional interaction between...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Physical and functional interaction between...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Physical and functional interaction between...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Protein Methyltransferases › Histone méthyltransférases › Histone-lysine N-methyltransferase › Physical and functional interaction between...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Physical and functional interaction between...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Physical and functional interaction between...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines corépressives › Complexe Sin3-histone désacétylases-corépresseurs › Physical and functional interaction between...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Physical and functional interaction between...