Chromosome errors in human eggs shape natural fertility over reproductive life span.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
27 09 2019
27 09 2019
Historique:
received:
05
12
2018
accepted:
04
09
2019
entrez:
12
10
2019
pubmed:
12
10
2019
medline:
31
3
2020
Statut:
ppublish
Résumé
Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.
Identifiants
pubmed: 31604276
pii: 365/6460/1466
doi: 10.1126/science.aav7321
pmc: PMC7212007
mid: EMS86142
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1466-1469Subventions
Organisme : European Research Council
ID : 337415
Pays : International
Organisme : European Research Council
ID : 724718
Pays : International
Organisme : Medical Research Council
ID : MR/M000664/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R35 GM133747
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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