Evaluation of the role of transhepatic flow in postoperative outcomes following major hepatectomy (THEFLOW): study protocol for a single-centre, non-interventional cohort study.
chemotherapy
major hepatectomy
small for size and flow syndrome
transhepatic flow
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
11 10 2019
11 10 2019
Historique:
entrez:
13
10
2019
pubmed:
13
10
2019
medline:
23
10
2020
Statut:
epublish
Résumé
Liver resection is the only curative treatment for primary and secondary hepatic tumours. Improvements in perioperative preparation of patients and new surgical developments have made complex liver resections possible. However, small for size and flow syndrome (SFSF) is still a challenging issue, rendering patients inoperable and causing postoperative morbidity and mortality. Although the role of transhepatic flow in the postoperative outcome has been shown in small partial liver transplantation and experimental studies of SFSF, this has never been studied in the clinical setting following liver resection. The aim of this study is to systematically evaluate transhepatic flow changes following major liver resection and its correlation with postoperative outcomes. The TransHEpatic FLOW (THEFLOW) study is a single-centre, non-interventional cohort study, and aims to enrol 50 patients undergoing major hepatectomy (defined as hemihepatectomy or extended hepatectomy based on the Brisbane classification) with or without prior chemotherapy. The portal venous flow, hepatic artery flow and portal venous pressure are measured before and after each resection. All patients are followed-up for 3 months after the operation. During each evaluation, standard clinical data, posthepatectomy liver failure and overall morbidity and mortality will be recorded. THEFLOW study was initiated on 25 March 2018 and is expected to progress for 2 years. This protocol study received approval from the Ethics Committee of the University of Heidelberg (registration number: S576/2017). The results of this study will be published in a peer-reviewed journal, and will also be presented at medical meetings. NCT03762876.
Identifiants
pubmed: 31604785
pii: bmjopen-2019-029618
doi: 10.1136/bmjopen-2019-029618
pmc: PMC6797302
doi:
Banques de données
ClinicalTrials.gov
['NCT03762876']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e029618Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Med Hypotheses. 2013 May;80(5):573-7
pubmed: 23428310
Br J Surg. 2001 Aug;88(8):1084-91
pubmed: 11488794
Can J Gastroenterol Hepatol. 2018 Nov 1;2018:1275720
pubmed: 30515369
Br J Surg. 2018 Sep;105(10):1254-1261
pubmed: 29999190
Ann Surg. 2003 Feb;237(2):256-64
pubmed: 12560784
J Am Coll Surg. 2000 Jul;191(1):38-46
pubmed: 10898182
Clin Res Hepatol Gastroenterol. 2016 Jun;40(3):267-275
pubmed: 26516057
HPB (Oxford). 2002;4(2):99; author reply 99-100
pubmed: 18332933
Dig Surg. 2012;29(1):6-17
pubmed: 22441614
Ann Surg. 2011 Jun;253(6):1102-10
pubmed: 21412143
World J Surg. 2017 Apr;41(4):1119-1125
pubmed: 27837237
Ann Surg. 2015 Nov;262(5):780-5; discussion 785-6
pubmed: 26583666
Can J Gastroenterol Hepatol. 2017;2017:5127178
pubmed: 28951864
Br J Surg. 2014 Feb;101(3):200-7
pubmed: 24402888
Gastroenterology. 2008 May;134(6):1752-63
pubmed: 18471552
Transplant Rev (Orlando). 2017 Apr;31(2):127-135
pubmed: 27989547
Liver Transpl. 2003 Sep;9(9):S36-41
pubmed: 12942477
Int J Surg. 2014;12(2):177-80
pubmed: 24370677
Liver Transpl. 2004 Feb;10(2):253-63
pubmed: 14762864
Visc Med. 2017 Dec;33(6):435-441
pubmed: 29344517
Ann Surg. 2001 Jul;234(1):63-70
pubmed: 11420484
Arch Surg. 2002 Jun;137(6):675-80; discussion 680-1
pubmed: 12049538
Ann Surg. 2006 Aug;244(2):254-9
pubmed: 16858188
Ann Surg. 2009 Aug;250(2):187-96
pubmed: 19638912
Br J Surg. 2018 Aug;105(9):1119-1127
pubmed: 30069876
J Am Coll Surg. 2015 Sep;221(3):717-728.e1
pubmed: 26232303
PLoS One. 2015 Dec 23;10(12):e0144019
pubmed: 26700646
J Gastrointest Surg. 2016 Mar;20(3):587-94
pubmed: 26573852
World J Gastroenterol. 2013 Nov 28;19(44):7922-9
pubmed: 24307786
Ann Surg. 2014 Nov;260(5):829-36; discussion 836-8
pubmed: 25379854
Surgery. 2011 May;149(5):713-24
pubmed: 21236455
Hepatogastroenterology. 2012 May;59(115):782-4
pubmed: 22020904
J Gastrointest Surg. 2003 Mar-Apr;7(3):325-30
pubmed: 12654556
Am J Transplant. 2005 Jun;5(6):1397-404
pubmed: 15888047