Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis.
Biomarkers
Circulating tumor cells
Diagnostics
High throughput
Image processing
Intratumor heterogeneity
Liquid biopsy
Morphometry
Physical oncology
Precision medicine
Journal
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
ISSN: 0080-0015
Titre abrégé: Recent Results Cancer Res
Pays: Germany
ID NLM: 0044671
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
13
10
2019
pubmed:
13
10
2019
medline:
28
10
2019
Statut:
ppublish
Résumé
Circulating tumor cells (CTCs) represent novel biomarkers, since they are obtainable through a simple and noninvasive blood draw or liquid biopsy. Here, we review the high-definition single-cell analysis (HD-SCA) workflow, which brings together modern methods of immunofluorescence with more sophisticated image processing to rapidly and accurately detect rare tumor cells among the milieu of platelets, erythrocytes, and leukocytes in the peripheral blood. In particular, we discuss progress in methods to measure CTC morphology and subcellular protein expression, and we highlight some initial applications that lead to fundamental new insights about the hematogenous phase of cancer, as well as its performance in early-stage diagnosis and treatment monitoring. We end with an outlook on how to further probe CTCs and the unique advantages of the HD-SCA workflow for improving the precision of cancer care.
Identifiants
pubmed: 31605225
doi: 10.1007/978-3-030-26439-0_5
pmc: PMC7679175
mid: NIHMS1621431
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-104Subventions
Organisme : NCI NIH HHS
ID : P30 CA014089
Pays : United States
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