The significance of PA28γ and U2AF1 in oral mucosal carcinogenesis.
PA28γ
U2AF1
bioinformatics
carcinogenesis
oral cancer
oral potentially malignant disorders
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
25
04
2019
revised:
20
09
2019
accepted:
06
10
2019
pubmed:
13
10
2019
medline:
23
1
2020
entrez:
13
10
2019
Statut:
ppublish
Résumé
Proteasome activator 28γ (PA28γ) upregulation plays a critical role in the carcinogenesis of many malignancies, including oral cancer. We aim to screen the related genes of PA28γ and investigate their function in oral mucosa carcinogenesis. Bioinformatics analysis was performed to screen the related genes of PA28γ. Immunohistochemical analysis was carried out to validate their correlation in oral squamous cell carcinoma (OSCC) and detect their expression levels in the whole process of oral mucosa carcinogenesis. The Kaplan-Meier method was used for estimating the overall survival, and the Cox models were constructed to predict the prognosis. U2 small nuclear RNA auxiliary factor 1 (U2AF1) was screened out, and the correlation between U2AF1 and PA28γ was further validated in OSCC. The expression levels of PA28γ and U2AF1 were gradually increased from normal to oral potentially malignant disorders (OPMD) to OSCC tissues. Overall survival was significantly shorter in patients with high U2AF1 expression and the combined application of U2AF1 and PA28γ notably improved the accuracy of prognosis prediction. U2AF1 and PA28γ might play pivotal roles in the progression of OPMD, which may provide insights into the development of new therapeutic strategies to prevent OPMD from becoming malignant.
Substances chimiques
Autoantigens
0
Ki antigen
0
Splicing Factor U2AF
0
U2AF1 protein, human
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Langues
eng
Pagination
53-61Subventions
Organisme : 111 Project of MOE China
ID : B14038
Organisme : National Natural Science Foundation of China
ID : 81672675
Organisme : National Natural Science Foundation of China
ID : 8162106
Organisme : National Natural Science Foundation of China
ID : 281771081
Organisme : National Natural Science Foundation of China
ID : 81872211
Organisme : National Natural Science Foundation of China
ID : 81472533
Organisme : National Key Research Program of China
ID : 2017YFC0840100
Organisme : National Key Research Program of China
ID : 2017YFC0840107
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.
Références
Abelson, S., Collord, G., Ng, S. W. K., Weissbrod, O., Mendelson Cohen, N., Niemeyer, E., … Shlush, L. I. (2018). Prediction of acute myeloid leukaemia risk in healthy individuals. Nature, 559(7714), 400-404. https://doi.org/10.1038/s41586-018-0317-6
Anderson, A., & Ishak, N. (2015). Marked variation in malignant transformation rates of oral leukoplakia. Evidence-Based Dentistry, 16(4), 102-103. https://doi.org/10.1038/sj.ebd.6401128
Chai, F., Liang, Y., Bi, J., Chen, L., Zhang, F., Cui, Y., & Jiang, J. (2015). REGgamma regulates ERalpha degradation via ubiquitin-proteasome pathway in breast cancer. Biochemical and Biophysical Research Communications, 456(1), 534-540. https://doi.org/10.1016/j.bbrc.2014.11.124
Chen, S., Huang, V., Xu, X., Livingstone, J., Soares, F., Jeon, J., … He, H. H. (2019). Widespread and functional RNA circularization in localized prostate cancer. Cell, 176(4), 831-843 e822. https://doi.org/10.1016/j.cell.2019.01.025
Chen, S., Wang, L., Xu, C., Chen, H., Peng, B., Xu, Y., … Zheng, J. (2017). Knockdown of REGgamma inhibits proliferation by inducing apoptosis and cell cycle arrest in prostate cancer. American Journal of Translational Research, 9(8), 3787-3795.
Desai, P., Mencia-Trinchant, N., Savenkov, O., Simon, M. S., Cheang, G., Lee, S., … Hassane, D. C. (2018). Somatic mutations precede acute myeloid leukemia years before diagnosis. Nature Medicine, 24(7), 1015-1023. https://doi.org/10.1038/s41591-018-0081-z
Ding, W. Q., Kuntz, S. M., & Miller, L. J. (2002). A misspliced form of the cholecystokinin-B/gastrin receptor in pancreatic carcinoma: Role of reduced cellular U2AF35 and a suboptimal 3′-splicing site leading to retention of the fourth intron. Cancer Research, 62(3), 947-952.
Global Burden of Disease Cancer Collaboration, Fitzmaurice, C., Allen, C., Barber, R. M., Barregard, L., Bhutta, Z. A., … Naghavi, M. (2017). Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncology, 3(4), 524-548. https://doi.org/10.1001/jamaoncol.2016.5688
Greenslade, R. (2017). Interventions for treating oral leukoplakia to prevent oral cancer. Nursing Standard, 31(39), 42-43. https://doi.org/10.7748/ns.2017.e10891
Ho, P. S., Wang, W. C., Huang, Y. T., & Yang, Y. H. (2019). Finding an oral potentially malignant disorder in screening program is related to early diagnosis of oral cavity cancer - Experience from real world evidence. Oral Oncology, 89, 107-114. https://doi.org/10.1016/j.oraloncology.2018.12.007
Ilagan, J. O., Ramakrishnan, A., Hayes, B., Murphy, M. E., Zebari, A. S., Bradley, P., & Bradley, R. K. (2015). U2AF1 mutations alter splice site recognition in hematological malignancies. Genome Research, 25(1), 14-26. https://doi.org/10.1101/gr.181016.114
Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., … Meyerson, M. (2012). Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell, 150(6), 1107-1120. https://doi.org/10.1016/j.cell.2012.08.029
Kondo, M., Moriishi, K., Wada, H., Noda, T., Marubashi, S., Wakasa, K., … Nagano, H. (2012). Upregulation of nuclear PA28gamma expression in cirrhosis and hepatocellular carcinoma. Experimental and Therapeutic Medicine, 3(3), 379-385. https://doi.org/10.3892/etm.2011.415
Li, J., Feng, X., Sun, C., Zeng, X., Xie, L., Xu, H., … Chen, Q. (2015). Associations between proteasomal activator PA28gamma and outcome of oral squamous cell carcinoma: Evidence from cohort studies and functional analyses. EBioMedicine, 2(8), 851-858. https://doi.org/10.1016/j.ebiom.2015.07.004
Li, J., Guo, Y. U., Feng, X., Wang, Z., Wang, Y., Deng, P., … Chen, Q. (2012). Receptor for activated C kinase 1 (RACK1): A regulator for migration and invasion in oral squamous cell carcinoma cells. Journal of Cancer Research and Clinical Oncology, 138(4), 563-571. https://doi.org/10.1007/s00432-011-1097-7
Li, L. P., Cheng, W. B., Li, H., Li, W., Yang, H., Wen, D. H., & Tang, Y. D. (2012). Expression of proteasome activator REGgamma in human laryngeal carcinoma and associations with tumor suppressor proteins. Asian Pacific Journal of Cancer Prevention, 13(6), 2699-2703.
Lin, H. Y., Cheng, C. H., Chen, D. T., Chen, Y. A., & Park, J. Y. (2016). Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer. Translational Cancer Research, 5(Suppl 5), S951-S963. https://doi.org/10.21037/tcr.2016.10.55
Lin, L., Wang, J., Liu, D., Liu, S., Xu, H., Ji, N., … Chen, Q. (2016). Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma. Scientific Reports, 6, 26757. https://doi.org/10.1038/srep26757
Liu, S., Liu, D., Zeng, X., Wang, J., Liu, J., Cheng, J., … Chen, Q. (2018). PA28gamma acts as a dual regulator of IL-6 and CCL2 and contributes to tumor angiogenesis in oral squamous cell carcinoma. Cancer Letters, 428, 192-200. https://doi.org/10.1016/j.canlet.2018.04.024
Mao, I., Liu, J., Li, X., & Luo, H. (2008). REGgamma, a proteasome activator and beyond? Cellular and Molecular Life Sciences, 65(24), 3971-3980. https://doi.org/10.1007/s00018-008-8291-z
Merendino, L., Guth, S., Bilbao, D., Martinez, C., & Valcarcel, J. (1999). Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG. Nature, 402(6763), 838-841. https://doi.org/10.1038/45602
Pacheco, T. R., Moita, L. F., Gomes, A. Q., Hacohen, N., & Carmo-Fonseca, M. (2006). RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts. Molecular Biology of the Cell, 17(10), 4187-4199. https://doi.org/10.1091/mbc.e06-01-0036
Panzarella, V., Pizzo, G., Calvino, F., Compilato, D., Colella, G., & Campisi, G. (2014). Diagnostic delay in oral squamous cell carcinoma: The role of cognitive and psychological variables. International Journal of Oral Science, 6(1), 39-45. https://doi.org/10.1038/ijos.2013.88
Petralia, F., Song, W. M., Tu, Z., & Wang, P. (2016). New method for joint network analysis reveals common and different coexpression patterns among genes and proteins in breast cancer. Journal of Proteome Research, 15(3), 743-754. https://doi.org/10.1021/acs.jproteome.5b00925
Ratajczak-Wrona, W., Jablonska, E., Antonowicz, B., Dziemianczyk, D., & Grabowska, S. Z. (2013). Levels of biological markers of nitric oxide in serum of patients with squamous cell carcinoma of the oral cavity. International Journal of Oral Science, 5(3), 141-145. https://doi.org/10.1038/ijos.2013.59
Rhodes, D. R., Yu, J., Shanker, K., Deshpande, N., Varambally, R., Ghosh, D., … Chinnaiyan, A. M. (2004). ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia, 6(1), 1-6. https://doi.org/10.1016/S1476-5586(04)80047-2
Richards, D. (2018a). Malignant transformation rates in Oral Lichen Planus. Evidence-Based Dentistry, 19(4), 122. https://doi.org/10.1038/sj.ebd.6401349
Richards, D. (2018b). Prevalence of oral potentially malignant disorders. Evidence-Based Dentistry, 19(4), 120-121. https://doi.org/10.1038/sj.ebd.6401348
Rivera, C. (2015). Essentials of oral cancer. International Journal of Clinical and Experimental Pathology, 8(9), 11884-11894.
Sakamoto, H., Yamashita, K., Okamoto, K., Kadowaki, T., Sakai, E., Umeda, M., & Tsukuba, T. (2018). Transcription factor EB influences invasion and migration in oral squamous cell carcinomas. Oral Diseases, 24(5), 741-748. https://doi.org/10.1111/odi.12826
Schlingemann, J., Habtemichael, N., Ittrich, C., Toedt, G., Kramer, H., Hambek, M., … Hahn, M. (2005). Patient-based cross-platform comparison of oligonucleotide microarray expression profiles. Laboratory Investigation, 85(8), 1024-1039. https://doi.org/10.1038/labinvest.3700293
Tomczak, K., Czerwinska, P., & Wiznerowicz, M. (2015). The Cancer Genome Atlas (TCGA): An immeasurable source of knowledge. Contemporary Oncology, 19(1A), A68-77. https://doi.org/10.5114/wo.2014.47136
Toruner, G. A., Ulger, C., Alkan, M., Galante, A. T., Rinaggio, J., Wilk, R., … Dermody, J. J. (2004). Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. Cancer Genetics and Cytogenetics, 154(1), 27-35. https://doi.org/10.1016/j.cancergencyto.2004.01.026
Vasko, V., Espinosa, A. V., Scouten, W., He, H., Auer, H., Liyanarachchi, S., … Ringel, M. D. (2007). Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion. Proceedings of the National Academy of Sciences of the United States of America, 104(8), 2803-2808. https://doi.org/10.1073/pnas.0610733104
Wang, X., Tu, S., Tan, J., Tian, T., Ran, L., Rodier, J. F., & Ren, G. (2011). REG gamma: A potential marker in breast cancer and effect on cell cycle and proliferation of breast cancer cell. Medical Oncology, 28(1), 31-41. https://doi.org/10.1007/s12032-010-9546-8
Wang, Z., Feng, X., Liu, X., Jiang, L. U., Zeng, X., Ji, N., … Chen, Q. (2009). Involvement of potential pathways in malignant transformation from oral leukoplakia to oral squamous cell carcinoma revealed by proteomic analysis. BMC Genomics, 10, 383. https://doi.org/10.1186/1471-2164-10-383
Wang, Z., Jiang, L. U., Huang, C., Li, Z., Chen, L., Gou, L., … Chen, Q. (2008). Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma. Molecular & Cellular Proteomics: MCP, 7(9), 1639-1650. https://doi.org/10.1074/mcp.M700520-MCP200
Warnakulasuriya, S., Johnson, N. W., & van der Waal, I. (2007). Nomenclature and classification of potentially malignant disorders of the oral mucosa. Journal of Oral Pathology and Medicine, 36(10), 575-580. https://doi.org/10.1111/j.1600-0714.2007.00582.x
Wu, S.-J., Tang, J.-L., Lin, C.-T., Kuo, Y.-Y., Li, L.-Y., Tseng, M.-H., … Tien, H.-F. (2013). Clinical implications of U2AF1 mutation in patients with myelodysplastic syndrome and its stability during disease progression. American Journal of Hematology, 88(11), E277-282. https://doi.org/10.1002/ajh.23541
Xie, K., Zhang, K., Kong, J., Wang, C., Gu, Y., Liang, C., … Hu, Z. (2018). Cancer-testis gene PIWIL1 promotes cell proliferation, migration, and invasion in lung adenocarcinoma. Cancer Medicine, 7(1), 157-166. https://doi.org/10.1002/cam4.1248
Xiong, S., Zheng, Y., Jiang, P., Liu, R., Liu, X., Qian, J., … Chu, Y. (2014). PA28gamma emerges as a novel functional target of tumour suppressor microRNA-7 in non-small-cell lung cancer. British Journal of Cancer, 110(2), 353-362. https://doi.org/10.1038/bjc.2013.728
Ye, H., Yu, T., Temam, S., Ziober, B. L., Wang, J., Schwartz, J. L., … Zhou, X. (2008). Transcriptomic dissection of tongue squamous cell carcinoma. BMC Genomics, 9, 69. https://doi.org/10.1186/1471-2164-9-69
Zorio, D. A., & Blumenthal, T. (1999). Both subunits of U2AF recognize the 3′ splice site in Caenorhabditis elegans. Nature, 402(6763), 835-838. https://doi.org/10.1038/45597