Incidence, Risk Factors, and Outcomes of Idiopathic Pneumonia Syndrome after Allogeneic Hematopoietic Cell Transplantation.

Adult Hematopoietic Stem Cell Transplantation / adverse effects Humans Incidence Pneumonia Retrospective Studies Risk Factors Transplantation Conditioning / adverse effects
Early complication of allogeneic hematopoietic cell transplantation Idiopathic pneumonia syndrome Noninfectious pulmonary syndromes

Journal

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Titre abrégé: Biol Blood Marrow Transplant
Pays: United States
ID NLM: 9600628

Informations de publication

Date de publication:
02 2020
Historique:
received: 02 07 2019
revised: 22 09 2019
accepted: 26 09 2019
pubmed: 13 10 2019
medline: 24 6 2021
entrez: 13 10 2019
Statut: ppublish

Résumé

Our current knowledge of idiopathic pneumonia syndrome (IPS) predates improved specificity in the diagnosis of IPS and advances in hematopoietic cell transplantation (HCT) and critical care practices. In this study, we describe and update the incidence, risk factors, and outcomes of IPS. We performed a retrospective cohort study of all adults who underwent allogeneic HCT at the Fred Hutchinson Cancer Research Center between 2006 and 2013 (n = 1829). IPS was defined using the National Heart, Lung, and Blood Institute consensus definition: multilobar airspace opacities on chest imaging, absence of lower respiratory tract infection, and hypoxemia. We described IPS incidence and mortality within 120 and 365 days after HCT. We examined conditioning intensity (nonmyeloablative versus myeloablative with high-dose total body irradiation [TBI] versus myeloablative with low-dose TBI) as an IPS risk factor in a time-to-event analysis using Cox models, controlled for age at transplant, HLA matching, stem cell source, and pretransplant Lung function Score (a combined measure of impairment in Forced Expiratory Volume in the first second (FEV

Identifiants

DOI: 10.1016/j.bbmt.2019.09.034 PMID: 31605819 PMC: PMC7035790
pubmed: 31605819
pii: S1083-8791(19)30654-8
doi: 10.1016/j.bbmt.2019.09.034
pmc: PMC7035790
mid: NIHMS1545647
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

413-420

Subventions

Organisme : NHLBI NIH HHS
ID : K12 HL087165
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007287
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States

Informations de copyright

Copyright © 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

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Auteurs

David S Wenger (DS)

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington Medical Center, Seattle, Washington. Electronic address: dswenger@uw.edu.

Matthew Triplette (M)

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington Medical Center, Seattle, Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Kristina Crothers (K)

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington Medical Center, Seattle, Washington; VA Puget Sound Healthcare System, University of Washington, Seattle, Washington.

Guang-Shing Cheng (GS)

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington Medical Center, Seattle, Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Joshua A Hill (JA)

Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington; Vaccine and Infectious Disease Division & Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Filippo Milano (F)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Division of Hematology and Oncology, Seattle Cancer Care Alliance, Seattle, Washington.

Shahida Shahrir (S)

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington Medical Center, Seattle, Washington.

Gary Schoch (G)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Lisa K Vande Vusse (LK)

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington Medical Center, Seattle, Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Incidence, Risk Factors, and Outcomes of...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Incidence, Risk Factors, and Outcomes of...
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