Phaeohyphomycosis due to Exophiala spinifera greatly improved by ALA-PDT: A case report.
ALA-PDT
Exophiala spinifera
ITS rDNA
Phaeohyphomycosis
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
12
07
2019
revised:
24
09
2019
accepted:
04
10
2019
pubmed:
14
10
2019
medline:
1
7
2020
entrez:
14
10
2019
Statut:
ppublish
Résumé
An 80-year-old women complained of painful erythema, papules, nodules on her right wrist for 9 months. Granuloma and inflammatory infiltrates with septate fungal hyphae were observed in pathological sections. Growth of demaciatious fungus on SDA was confirmed to be Exophiala spinifera by microscopic appearance and ITS rDNA sequencing. The diagnosis of phaeohyphomycosis due to E. spinifera was established. The patient had a poor response to oral itraconazole (200 mg/d) combining with terbinafine (250 mg/d) for 6 weeks. Then, following three courses of ALA-PDT, used as adjuvant therapy, skin lesions greatly improved and remained stable after 3 months follow-up. The case suggests that ALA-PDT is an effective adjuvant treatment option for patients with recalcitrant local subcutaneous fungal infection.
Identifiants
pubmed: 31606515
pii: S1572-1000(19)30342-4
doi: 10.1016/j.pdpdt.2019.10.002
pii:
doi:
Substances chimiques
Photosensitizing Agents
0
Aminolevulinic Acid
88755TAZ87
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
297-299Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.