Local Management of Anogenital Warts in Non-immunocompromised Adults: A Systematic Review and Meta-analyses of Randomized Controlled Trials.
Anogenital warts
Condyloma
Cryotherapy
Genital
Meta-analysis
Systematic review
Journal
Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
29
07
2019
pubmed:
14
10
2019
medline:
14
10
2019
entrez:
14
10
2019
Statut:
ppublish
Résumé
Several therapeutic options are available to manage anogenital warts (AGWs). However, no hierarchy of treatments is provided in the latest European and American recommendations. This study aimed to determine the efficacy and safety of local treatments for the management of AGWs. A search was conducted through 12 databases from inception to August 2018. All randomized controlled trials (RCTs) in which at least one parallel treatment group composed of immunocompetent adults with AGWs received at least one provider-administered or patient-administered treatment were included. Risk of bias assessment and meta-analyses of aggregated study data were performed on the basis of the Cochrane Handbook, and quality of evidence evaluation followed the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach. Primary endpoints were complete clearance and recurrence at 3 months. Seventy RCTs (9931 patients) were included. All but four RCTs had a high risk of bias. CO The vast majority of included RCTs had a low level of evidence, thereby preventing the establishment of a hierarchy of treatments. Nevertheless, our results provide an overview of the main AGW treatments available for general practitioners and specialists. While provider-administered treatments are superior, patient-administered treatments (e.g., imiquimod, podophyllotoxin) are useful solutions for compliant patients. PROSPERO-CRD42015025827.
Identifiants
pubmed: 31606873
doi: 10.1007/s13555-019-00328-z
pii: 10.1007/s13555-019-00328-z
pmc: PMC6828858
doi:
Types de publication
Journal Article
Langues
eng
Pagination
761-774Subventions
Organisme : Programme Hospitalier de Recherche Clinique Interrégional
ID : 13 069
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