Wallerian Degeneration of the Cerebral Peduncle and Association with Motor Outcome in Childhood Stroke.
Adolescent
Brain Ischemia
/ complications
Cerebral Arterial Diseases
/ complications
Cerebral Peduncle
/ diagnostic imaging
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Infant
Magnetic Resonance Imaging
Male
Motor Disorders
/ etiology
Outcome Assessment, Health Care
Paresis
/ etiology
Retrospective Studies
Seizures
/ etiology
Stroke
/ complications
Wallerian Degeneration
/ diagnostic imaging
Cerebrovascular disease
Imaging
Magnetic resonance imaging (MRI)
Motor outcome
Pediatrics
Stroke
T2-weighted MRI
Wallerian degeneration
Journal
Pediatric neurology
ISSN: 1873-5150
Titre abrégé: Pediatr Neurol
Pays: United States
ID NLM: 8508183
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
01
06
2019
accepted:
12
07
2019
pubmed:
15
10
2019
medline:
15
12
2020
entrez:
15
10
2019
Statut:
ppublish
Résumé
To evaluate the presence of Wallerian degeneration and its relationship with sensorimotor deficits following childhood-onset arterial ischemic stroke (AIS). Children surviving unilateral AIS older than one month of age were assessed for severity of sensorimotor neurological deficit with the Pediatric Stroke Outcome Measure at least one year post stroke (mean follow-up = 2.9 years, S.D. = ±1.6). The area (mm Asymmetry was compared in 52 children with stroke (cases) and 20 controls (normal brain MRIs). The AI was greater in patients with stroke (mean = 6.8%, S.D. = ±5.9) compared with controls (mean = 3.4%, S.D. = ±3.5, P < 0.02). Patients with poor outcome had an AI of 10% or greater compared with patients with good outcome (mean 10.4 versus 4, P < 0.001), and the AI was moderately correlated with motor deficit severity (r = 0.582, P = 0.001). Asymmetry of the cerebral peduncle is a feasible method of assessing Wallerian degeneration in children with unilateral AIS. The degree of asymmetry in the cerebral peduncles was moderately correlated with neurological outcome severity and reflects the degree of motor deficit in children following stroke.
Sections du résumé
BACKGROUND
To evaluate the presence of Wallerian degeneration and its relationship with sensorimotor deficits following childhood-onset arterial ischemic stroke (AIS).
METHODS
Children surviving unilateral AIS older than one month of age were assessed for severity of sensorimotor neurological deficit with the Pediatric Stroke Outcome Measure at least one year post stroke (mean follow-up = 2.9 years, S.D. = ±1.6). The area (mm
RESULTS
Asymmetry was compared in 52 children with stroke (cases) and 20 controls (normal brain MRIs). The AI was greater in patients with stroke (mean = 6.8%, S.D. = ±5.9) compared with controls (mean = 3.4%, S.D. = ±3.5, P < 0.02). Patients with poor outcome had an AI of 10% or greater compared with patients with good outcome (mean 10.4 versus 4, P < 0.001), and the AI was moderately correlated with motor deficit severity (r = 0.582, P = 0.001).
CONCLUSIONS
Asymmetry of the cerebral peduncle is a feasible method of assessing Wallerian degeneration in children with unilateral AIS. The degree of asymmetry in the cerebral peduncles was moderately correlated with neurological outcome severity and reflects the degree of motor deficit in children following stroke.
Identifiants
pubmed: 31607421
pii: S0887-8994(19)30533-8
doi: 10.1016/j.pediatrneurol.2019.07.004
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
67-73Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.