Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations.

Data Accuracy Genetic Variation Genetics, Population / methods Genome-Wide Association Study / methods Genotyping Techniques / methods Human Genetics / methods Humans Pedigree
GWAS admixed populations ancestry complex disease cross-ancestry diversity population genetics psychiatry trans-ancestry trans-ethnic

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
17 10 2019
Historique:
received: 26 03 2019
revised: 10 07 2019
accepted: 26 08 2019
pubmed: 15 10 2019
medline: 28 5 2020
entrez: 15 10 2019
Statut: ppublish

Résumé

Genome-wide association studies (GWASs) have focused primarily on populations of European descent, but it is essential that diverse populations become better represented. Increasing diversity among study participants will advance our understanding of genetic architecture in all populations and ensure that genetic research is broadly applicable. To facilitate and promote research in multi-ancestry and admixed cohorts, we outline key methodological considerations and highlight opportunities, challenges, solutions, and areas in need of development. Despite the perception that analyzing genetic data from diverse populations is difficult, it is scientifically and ethically imperative, and there is an expanding analytical toolbox to do it well.

Identifiants

DOI: 10.1016/j.cell.2019.08.051 PMID: 31607513 PMC: PMC6939869
pubmed: 31607513
pii: S0092-8674(19)31002-5
doi: 10.1016/j.cell.2019.08.051
pmc: PMC6939869
mid: NIHMS1546248
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

589-603

Subventions

Organisme : NIMH NIH HHS
ID : U01 MH109499
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK114379
Pays : United States
Organisme : Medical Research Council
ID : MR/S003061/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U01 MH109514
Pays : United States
Organisme : NIMH NIH HHS
ID : K99 MH117229
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI139012
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH094432
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109528
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109536
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109501
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG009649
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001085
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH113848
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109532
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U01 MH109539
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Références

Nature. 2017 Jul 13;547(7662):173-178
pubmed: 28658209
Behav Brain Sci. 2010 Jun;33(2-3):61-83; discussion 83-135
pubmed: 20550733
Nat Rev Genet. 2018 Aug;19(8):491-504
pubmed: 29844615
Nat Genet. 2006 Jun;38(6):659-62
pubmed: 16715099
PLoS Genet. 2018 Dec 27;14(12):e1007309
pubmed: 30589851
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
Nat Commun. 2018 Nov 7;9(1):4674
pubmed: 30405126
Nat Rev Genet. 2018 Mar;19(3):175-185
pubmed: 29151588
Br J Psychiatry. 2010 Sep;197(3):170-1
pubmed: 20807958
Nat Genet. 2019 Dec;51(12):1670-1678
pubmed: 31740837
Nat Biotechnol. 2019 Mar;37(3):220-224
pubmed: 30833764
Hum Genomics. 2015 Jan 07;9:1
pubmed: 25563503
Bipolar Disord. 2018 Sep;20(6):506-514
pubmed: 29527766
Circulation. 2011 Apr 19;123(15):1661-70
pubmed: 21502584
Sci Rep. 2017 Jul 27;7(1):6733
pubmed: 28751670
Am J Hum Genet. 2015 Aug 6;97(2):260-71
pubmed: 26189819
Am J Addict. 2017 Aug;26(5):494-501
pubmed: 28714599
Trends Genet. 2015 Mar;31(3):117-9
pubmed: 25601285
PLoS Comput Biol. 2015 Apr 17;11(4):e1004219
pubmed: 25885710
Am Psychol. 2014 Apr;69(3):249-68
pubmed: 24750075
Am J Hum Genet. 2013 Jul 11;93(1):42-53
pubmed: 23768515
Nat Commun. 2018 May 8;9(1):1825
pubmed: 29739930
PLoS One. 2018 Dec 6;13(12):e0207677
pubmed: 30521541
Nature. 2015 Oct 1;526(7571):75-81
pubmed: 26432246
PLoS One. 2017 Nov 29;12(11):e0188466
pubmed: 29186155
Genetics. 2015 Aug;200(4):1285-95
pubmed: 26092716
Genet Med. 2017 Mar;19(3):345-351
pubmed: 27632687
Methods Mol Biol. 2018;1793:51-71
pubmed: 29876891
PLoS Genet. 2013 Jun;9(6):e1003566
pubmed: 23785302
Psychol Med. 2002 May;32(4):585-94
pubmed: 12102373
Genetics. 2018 Apr;208(4):1351-1355
pubmed: 29618592
Nat Genet. 2012 Jul 22;44(8):955-9
pubmed: 22820512
Genome Biol. 2016 Jul 14;17(1):157
pubmed: 27418169
PLoS Med. 2017 Sep 12;14(9):e1002383
pubmed: 28898252
Am J Hum Genet. 2016 Jul 7;99(1):76-88
pubmed: 27321947
Nat Neurosci. 2018 Dec;21(12):1656-1669
pubmed: 30482948
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Nat Genet. 2018 Jul;50(7):906-908
pubmed: 29892013
Int J Epidemiol. 2011 Dec;40(6):1652-66
pubmed: 22158673
Genet Epidemiol. 2015 Mar;39(3):149-55
pubmed: 25536929
Genet Epidemiol. 2019 Mar;43(2):180-188
pubmed: 30474154
Genome Med. 2014 Oct 31;6(10):91
pubmed: 25473427
Pharmgenomics Pers Med. 2018 Apr 10;11:59-66
pubmed: 29692621
Genome Biol. 2016 Mar 08;17:44
pubmed: 26956719
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7377-82
pubmed: 27382152
Nature. 2005 Oct 27;437(7063):1299-320
pubmed: 16255080
Eur J Epidemiol. 2015 Apr;30(4):317-30
pubmed: 25762173
Nature. 2014 Aug 14;512(7513):190-3
pubmed: 25043022
Am J Hum Genet. 2005 Oct;77(4):519-32
pubmed: 16175499
Nat Genet. 2019 Apr;51(4):584-591
pubmed: 30926966
Alcohol Clin Exp Res. 2018 Dec;42(12):2281-2297
pubmed: 30320893
Nat Genet. 2016 Sep;48(9):1049-1054
pubmed: 27455349
N Engl J Med. 2016 Aug 18;375(7):655-65
pubmed: 27532831
Genome Biol. 2017 Apr 27;18(1):77
pubmed: 28449691
Nature. 2019 Jun;570(7762):514-518
pubmed: 31217584
Am J Hum Genet. 2015 Jul 2;97(1):35-53
pubmed: 26094574
Nature. 2018 Oct;562(7726):203-209
pubmed: 30305743
Nat Genet. 2018 Nov;50(11):1505-1513
pubmed: 30297969
Am J Hum Genet. 2012 Jul 13;91(1):122-38
pubmed: 22748210
Genet Epidemiol. 2017 Dec;41(8):811-823
pubmed: 29110330
Transl Psychiatry. 2017 Mar 28;7(3):e1074
pubmed: 28350396
Genet Epidemiol. 2014 Jan;38(1):10-20
pubmed: 24248908
Per Med. 2018 Sep;15(5):403-412
pubmed: 30209973
Nature. 2016 Oct 12;538(7624):161-164
pubmed: 27734877
Commun Biol. 2019 Jan 7;2:9
pubmed: 30623105
Addict Biol. 2019 Jan;24(1):132-144
pubmed: 29178570
Nat Genet. 2018 Sep;50(9):1219-1224
pubmed: 30104762
Cell. 2019 Mar 21;177(1):26-31
pubmed: 30901543
Nat Genet. 2014 Dec;46(12):1356-62
pubmed: 25383972
Nat Commun. 2018 Jul 27;9(1):2957
pubmed: 30054469
Genet Epidemiol. 2013 Dec;37(8):787-801
pubmed: 24123217
Psychol Med. 2015 Jul;45(9):1945-54
pubmed: 25781917
JAMA Psychiatry. 2017 Feb 1;74(2):162-168
pubmed: 28002544
Genet Epidemiol. 2019 Feb;43(1):50-62
pubmed: 30368908
Nat Genet. 2004 May;36(5):512-7
pubmed: 15052271

Auteurs

Roseann E Peterson (RE)

Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address: roseann.peterson@vcuhealth.org.

Karoline Kuchenbaecker (K)

Division of Psychiatry and UCL Genetics Institute, University College London, London W1T 7NF, UK.

Raymond K Walters (RK)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Chia-Yen Chen (CY)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Alice B Popejoy (AB)

Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Sathish Periyasamy (S)

Queensland Brain Institute and Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, QLD 4072, Australia.

Max Lam (M)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Conrad Iyegbe (C)

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.

Rona J Strawbridge (RJ)

Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 8RZ, UK; Department of Medicine Solna, Karolinska Institute, Stockholm, SE 17176, Sweden.

Leslie Brick (L)

Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI 02906, USA.

Caitlin E Carey (CE)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

Alicia R Martin (AR)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Jacquelyn L Meyers (JL)

Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA.

Jinni Su (J)

Department of Psychology, Arizona State University, Tempe, AZ 85281, USA.

Junfang Chen (J)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany.

Alexis C Edwards (AC)

Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA.

Allan Kalungi (A)

Mental Health Section of MRC/UVRI and LSHTM Uganda Research Unit, P.O. Box 49, Entebbe, Uganda; Department of Psychiatry, Faculty of Medicine & Health Sciences, University of Stellenbosch, Cape Town, South Africa; Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda; Global Initiative for Neuropsychiatric Genetics Education in Research, Harvard T.H. Chan School of Public Health and Broad Institute, Boston, MA 02115, USA.

Nastassja Koen (N)

Department of Psychiatry, Faculty of Medicine & Health Sciences, University of Stellenbosch, Cape Town, South Africa; Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda; Global Initiative for Neuropsychiatric Genetics Education in Research, Harvard T.H. Chan School of Public Health and Broad Institute, Boston, MA 02115, USA.

Lerato Majara (L)

Global Initiative for Neuropsychiatric Genetics Education in Research, Harvard T.H. Chan School of Public Health and Broad Institute, Boston, MA 02115, USA; MRC Human Genetics Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, 7925, South Africa.

Emanuel Schwarz (E)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany.

Jordan W Smoller (JW)

Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Eli A Stahl (EA)

Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Patrick F Sullivan (PF)

Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE 17176, Sweden; Genetics and Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Evangelos Vassos (E)

Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.

Bryan Mowry (B)

Queensland Brain Institute and Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, QLD 4072, Australia.

Miguel L Prieto (ML)

Department of Psychiatry, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile; Mental Health Service, Clínica Universidad de los Andes, Santiago 7620001, Chile; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Alfredo Cuellar-Barboza (A)

Department of Psychiatry, University Hospital and School of Medicine, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Tim B Bigdeli (TB)

Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA.

Howard J Edenberg (HJ)

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Hailiang Huang (H)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Laramie E Duncan (LE)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.

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