Somatic copy number alterations in pleomorphic adenoma and recurrent pleomorphic adenoma.

Adenoma, Pleomorphic Comparative Genomic Hybridization DNA Copy Number Variations Humans Transcription Factors / genetics

Journal

Oral surgery, oral medicine, oral pathology and oral radiology
ISSN: 2212-4411
Titre abrégé: Oral Surg Oral Med Oral Pathol Oral Radiol
Pays: United States
ID NLM: 101576782

Informations de publication

Date de publication:
Jan 2020
Historique:
received: 10 04 2019
revised: 07 08 2019
accepted: 25 08 2019
pubmed: 15 10 2019
medline: 28 8 2020
entrez: 15 10 2019
Statut: ppublish

Résumé

As the genetic changes in recurrent pleomorphic adenoma (RPA) have not yet been investigated, the aim of this study was to assess the genomic profile of somatic copy number alteration in RPA and pleomorphic adenoma (PA) by using array comparative genomic hybridization (aCGH). Four cases of RPA and 13 cases of PA were evaluated by using aCGH, using a 180 K platform. Data were analyzed by using Nexus Copy Number Discovery. The RPA group rarely showed any copy number alteration, except for 1 case that exhibited losses in 5 p15.33 p15.1, 5 q13.1 q35.3 and 12 q12 q13.11. The PA group also showed few copy number alterations, and the most frequent findings involved chromosomes 8: 8p21.3-p12 (gain), 8q12.1 (loss), 8p23.3-q24.3 (gain), and 8q12.1-q21.11 (gain). Genomic amplifications were revealed in the PA group, and the relevant affected genes were MAML2 and LIFR. PA and RPA exhibit few somatic copy number alterations and show a similar genomic profile on aCGH.

Identifiants

DOI: 10.1016/j.oooo.2019.08.016 PMID: 31607675
pubmed: 31607675
pii: S2212-4403(19)31422-1
doi: 10.1016/j.oooo.2019.08.016
pii:
doi:

Substances chimiques

Transcription Factors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

59-64

Informations de copyright

Copyright © 2019. Published by Elsevier Inc.

Auteurs

Fernanda Viviane Mariano (FV)

Pathology Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil. Electronic address: fevimariano@gmail.com.

Felipe Fidalgo (F)

International Research Center, AC Camargo Cancer Center, São Paulo-SP, Brazil.

André Luís Maion Casarim (ALM)

Head and Neck Surgery Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil.

Antônio Santos Martins (AS)

Head and Neck Surgery Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil.

João Figueira Scarini (JF)

Oral Pathology Department, Piracicaba Dental School/UNICAMP, Piracicaba-SP, Brazil.

Reydson Alcides de Lima Souza (RA)

Oral Pathology Department, Piracicaba Dental School/UNICAMP, Piracicaba-SP, Brazil.

Erika Said Egal (ES)

Pathology Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil.

Luiz Paulo Kowalski (LP)

Head and Neck Surgery Department, AC Camargo Cancer Center, São Paulo-SP, Brazil.

Ana Cristina Victorino Krepischi (ACV)

Department of Genetics and Evolutionary Biology, Institute of Biosciences, USP, São Paulo-SP, Brazil.

Albina Altemani (A)

Pathology Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Adénomes › Adénome pléomorphe › Somatic copy number alterations in pleomorphic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Hybridation génomique comparative › Somatic copy number alterations in pleomorphic...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variation structurale du génome › Variations de nombre de copies de segment d'ADN › Somatic copy number alterations in pleomorphic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Somatic copy number alterations in pleomorphic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Somatic copy number alterations in pleomorphic...