Fractalkine Modulates Microglia Metabolism in Brain Ischemia.
CX3CL1
ischemia
microglia
neuroinflammation
neuroprotection
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
01
2019
accepted:
27
08
2019
entrez:
15
10
2019
pubmed:
15
10
2019
medline:
15
10
2019
Statut:
epublish
Résumé
In the CNS, the chemokine CX3CL1 (fractalkine) is expressed on neurons while its specific receptor CX3CR1 is expressed on microglia and macrophages. Microglia play an important role in health and disease through CX3CL1/CX3CR1 signaling, and in many neurodegenerative disorders, microglia dysregulation has been associated with neuro-inflammation. We have previously shown that CX3CL1 has neuroprotective effects against cerebral ischemia injury. Here, we investigated the involvement of CX3CL1 in the modulation of microglia phenotype and the underlying neuroprotective effect on ischemia injury. The expression profiles of anti- and pro-inflammatory genes showed that CX3CL1 markedly inhibited microglial activation both
Identifiants
pubmed: 31607865
doi: 10.3389/fncel.2019.00414
pmc: PMC6755341
doi:
Types de publication
Journal Article
Langues
eng
Pagination
414Informations de copyright
Copyright © 2019 Lauro, Chece, Monaco, Antonangeli, Peruzzi, Rinaldo, Paone, Cutruzzolà and Limatola.
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