Novel Y-Chromosome Long Non-Coding RNAs Expressed in Human Male CNS During Early Development.
Pan troglodytes
RNA sequencing
X-chromosome
Y-chromosome
gene expression
human brain development
long non-coding RNA
sex differences
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
06
2018
accepted:
23
08
2019
entrez:
15
10
2019
pubmed:
15
10
2019
medline:
15
10
2019
Statut:
epublish
Résumé
Global microarray gene expression analyses previously demonstrated differences in female and male embryos during neurodevelopment. In particular, before sexual maturation of the gonads, the differences seem to concentrate on the expression of genes encoded on the X- and Y-chromosomes. To investigate genome-wide differences in expression during this early developmental window, we combined high-resolution RNA sequencing with qPCR to analyze brain samples from human embryos during the first trimester of development. Our analysis was tailored for maximum sensitivity to discover Y-chromosome gene expression, but at the same time, it was underpowered to detect X-inactivation escapees. Using this approach, we found that 5 out of 13 expressed gametolog pairs showed unbalanced gene dosage, and as a consequence, a male-biased expression. In addition, we found six novel non-annotated long non-coding RNAs on the Y-chromosome with conserved expression patterns in newborn chimpanzee. The tissue specific and time-restricted expression of these long non-coding RNAs strongly suggests important functions during central nervous system development in human males.
Identifiants
pubmed: 31608120
doi: 10.3389/fgene.2019.00891
pmc: PMC6769107
doi:
Types de publication
Journal Article
Langues
eng
Pagination
891Informations de copyright
Copyright © 2019 Johansson, Pottmeier, Suciu, Ahmad, Zaghlool, Halvardson, Darj, Feuk, Peuckert and Jazin.
Références
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Nature. 2017 Oct 11;550(7675):244-248
pubmed: 29022598
Nat Rev Neurosci. 2010 Jan;11(1):9-17
pubmed: 20019686
Hum Mol Genet. 2002 Jun 1;11(12):1409-19
pubmed: 12023983
Genes Dev. 2011 Sep 15;25(18):1915-27
pubmed: 21890647
Nature. 2011 Oct 26;478(7370):483-9
pubmed: 22031440
PLoS One. 2013;8(2):e56611
pubmed: 23437185
Nat Biotechnol. 2010 May;28(5):511-5
pubmed: 20436464
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Bioinformatics. 2010 Oct 1;26(19):2438-44
pubmed: 20709693
Nucleic Acids Res. 2012 Jan;40(Database issue):D1077-81
pubmed: 22064864
Science. 2018 Dec 14;362(6420):
pubmed: 30545855
Biol Sex Differ. 2017 Aug 17;8(1):28
pubmed: 28818098
J Proteome Res. 2015 Sep 4;14(9):3474-83
pubmed: 26144214
Genome Biol. 2014;15(12):550
pubmed: 25516281
Nature. 2003 Jun 19;423(6942):825-37
pubmed: 12815422
Crit Rev Biochem Mol Biol. 2014 Jan-Feb;49(1):16-32
pubmed: 24164576
Nat Rev Neurosci. 2006 Jun;7(6):477-84
pubmed: 16688123
Nature. 1998 Aug 20;394(6695):776-80
pubmed: 9723615
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6062-7
pubmed: 15075390
PLoS One. 2013 Aug 14;8(8):e71152
pubmed: 23967161
Nat Commun. 2013;4:2771
pubmed: 24264146
Nature. 2012 Sep 6;489(7414):91-100
pubmed: 22955619
Annu Rev Neurosci. 1984;7:413-42
pubmed: 6370082
Cancer Res. 2001 Feb 15;61(4):1652-8
pubmed: 11245479
Nat Rev Genet. 2014 Jun;15(6):367-78
pubmed: 24733023
Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):82-90
pubmed: 14559357
Nature. 2014 Apr 10;508(7495):199-206
pubmed: 24695229
Nucleic Acids Res. 2018 Jan 4;46(D1):D308-D314
pubmed: 29140524
Genome Biol. 2010;11(10):R106
pubmed: 20979621
RNA. 2014 Jul;20(7):1103-11
pubmed: 24847104
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
J Endocrinol. 1980 Sep;86(3):483-8
pubmed: 7430908
Front Neurol. 2015 Mar 09;6:45
pubmed: 25806019
Brain Res. 2006 Dec 18;1126(1):50-5
pubmed: 16962077
Arch Sex Behav. 1974 Jan;3(1):51-90
pubmed: 4202643
Nat Neurosci. 2011 Jun;14(6):677-83
pubmed: 21613996
Nature. 2001 Feb 15;409(6822):860-921
pubmed: 11237011
BMC Genomics. 2012 Nov 10;13:607
pubmed: 23140559
Sci Rep. 2017 Dec 1;7(1):16710
pubmed: 29196750
Nat Genet. 2015 Mar;47(3):199-208
pubmed: 25599403
Nat Rev Neurosci. 2004 Sep;5(9):701-8
pubmed: 15322528
Front Genet. 2015 Jan 26;6:2
pubmed: 25674102
BMC Genomics. 2010 Nov 03;11:614
pubmed: 21047393
Eur J Obstet Gynecol Reprod Biol. 2003 Oct 10;110(2):224-9
pubmed: 12969589
Adv Sex Horm Res. 1977;3:139-68
pubmed: 401554
Brief Funct Genomics. 2017 Jul 1;16(4):194-204
pubmed: 27687708
Biol Sex Differ. 2016 Jan 12;7:5
pubmed: 26759715
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Mol Psychiatry. 2009 Nov;14(11):987, 988-9
pubmed: 19851278
Nucleic Acids Res. 2018 Jan 4;46(D1):D246-D251
pubmed: 29165655