D. melanogaster
HIF1α
Warburg effect
aerobic glycolysis
bacterial infection
immunology
immunometabolism
inflammation
polarization of macrophages
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
14 10 2019
14 10 2019
Historique:
received:
25
07
2019
accepted:
12
10
2019
pubmed:
15
10
2019
medline:
9
4
2020
entrez:
15
10
2019
Statut:
epublish
Résumé
Macrophage-mediated phagocytosis and cytokine production represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory response in mammals is the complex remodeling of cellular metabolism towards aerobic glycolysis. Although the function of bactericidal macrophages is highly conserved, the metabolic remodeling of insect macrophages remains poorly understood. Here, we used adults of the fruit fly
Identifiants
pubmed: 31609200
doi: 10.7554/eLife.50414
pii: 50414
pmc: PMC6867711
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM119557
Pays : United States
Organisme : Grantová Agentura České Republiky
ID : Project 17-16406S
Pays : International
Organisme : Czech Science Foundation
ID : Project 17-16406S
Pays : International
Organisme : NIGMS NIH HHS
ID : R35 MIRA 1R35GM119557
Pays : United States
Informations de copyright
© 2019, Krejčová et al.
Déclaration de conflit d'intérêts
GK, AD, PN, MK, LS, GC, JT, JL, MJ, TD, AB No competing interests declared
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