Novel halogenated synthetic cannabinoids impair sensorimotor functions in mice.

Animals Behavior, Animal / drug effects Cannabinoids / chemistry Halogenation Illicit Drugs / toxicity Indoles / chemistry Male Mice, Inbred ICR Naphthalenes / chemistry Psychomotor Performance / drug effects
AM-2201 JWH-018-Br JWH-018-Cl Prepulse inhibition Sensorimotor responses Synthetic cannabinoids

Journal

Neurotoxicology
ISSN: 1872-9711
Titre abrégé: Neurotoxicology
Pays: Netherlands
ID NLM: 7905589

Informations de publication

Date de publication:
01 2020
Historique:
received: 30 01 2019
revised: 18 09 2019
accepted: 07 10 2019
pubmed: 15 10 2019
medline: 21 1 2021
entrez: 15 10 2019
Statut: ppublish

Résumé

JWH-018-Cl, JWH-018-Br and AM-2201 (JWH-018 halogenated-derivatives; JWH-018-R compounds) are synthetic cannabinoid agonists illegally marketed as "Spice", "K2", "herbal blend" and research chemicals for their cannabis-like psychoactive effects. In rodents, JWH-018 and its halogenated derivatives reproduce the typical effects of Δ

Identifiants

DOI: 10.1016/j.neuro.2019.10.002 PMID: 31610187
pubmed: 31610187
pii: S0161-813X(19)30109-3
doi: 10.1016/j.neuro.2019.10.002
pii:
doi:

Substances chimiques

Cannabinoids 0
Illicit Drugs 0
Indoles 0
Naphthalenes 0
1-pentyl-3-(1-naphthoyl)indole G391998J57

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

17-32

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Sabrine Bilel (S)

Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, Italy.

Micaela Tirri (M)

Department of Morphology, Experimental Medicine and Surgery, Section of Legal Medicine, University of Ferrara, Ferrara, Italy.

Raffaella Arfè (R)

Institute of Public Health, Section of Legal Medicine, Catholic University of Rome, Rome, Italy.

Andrea Ossato (A)

Institute of Public Health, Section of Legal Medicine, Catholic University of Rome, Rome, Italy.

Claudio Trapella (C)

Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, Italy.

Giovanni Serpelloni (G)

Drug Policy Institute, Department of Psychiatry in the College of Medicine, University of Florida, USA.

Margherita Neri (M)

Department of Morphology, Experimental Medicine and Surgery, Section of Legal Medicine, University of Ferrara, Ferrara, Italy.

Liana Fattore (L)

Institute of Neuroscience-Cagliari, National Research Council, Italy. Electronic address: liana.fattore@in.cnr.it.

Matteo Marti (M)

Department of Morphology, Experimental Medicine and Surgery, Section of Legal Medicine, University of Ferrara, Ferrara, Italy; Center for Neuroscience and National Institute of Neuroscience, Italy; Collaborative Center for the Italian National Early Warning System, Department of Anti-Drug Policies, Presidency of the Council of Ministers, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Novel halogenated synthetic cannabinoids...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Novel halogenated synthetic cannabinoids...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Novel halogenated synthetic cannabinoids...
questionsmedicales.fr › Métabolisme › Halogénation › Novel halogenated synthetic cannabinoids...
questionsmedicales.fr › Préparations pharmaceutiques › Substances illicites › Novel halogenated synthetic cannabinoids...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Novel halogenated synthetic cannabinoids...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée ICR › Novel halogenated synthetic cannabinoids...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Novel halogenated synthetic cannabinoids...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Performance psychomotrice › Novel halogenated synthetic cannabinoids...