Physical activity may drive healthy microvascular ageing via downregulation of p66
Age Factors
Aged
Arterioles
/ physiology
Biomarkers
/ blood
Cross-Sectional Studies
DNA Methylation
Down-Regulation
Exercise
Female
Healthy Aging
/ blood
Humans
Male
Middle Aged
Oxidative Stress
Retinal Vessels
/ physiology
Sedentary Behavior
Src Homology 2 Domain-Containing, Transforming Protein 1
/ blood
Tyrosine
/ analogs & derivatives
Venules
/ physiology
Ageing
DNA methylation
oxidative stress
p66Shc
retinal microcirculation
Journal
European journal of preventive cardiology
ISSN: 2047-4881
Titre abrégé: Eur J Prev Cardiol
Pays: England
ID NLM: 101564430
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
pubmed:
16
10
2019
medline:
22
12
2020
entrez:
16
10
2019
Statut:
ppublish
Résumé
Narrower retinal arterioles and wider venules are linked to adverse cardiovascular outcomes. The mitochondrial adaptor p66 Altogether 158 subjects were included in the study (mean age 59.4 ± 7.0 years). Thirty-eight subjects were healthy active, 36 were healthy sedentary and 84 were sedentary with ≥2 cardiovascular risk factors. Retinal arteriolar and venular diameters were measured by means of a retinal vessel analyser. As a marker of oxidative stress, plasma 3-nitrotyrosine was determined by enzyme-linked immunosorbent assay. Gene expression of p66 Wider retinal arterioles (179 ± 14 vs 172 ± 11 and 171 ± 14 µm; Long-term physical activity-induced DNA methylation of p66
Sections du résumé
BACKGROUND
Narrower retinal arterioles and wider venules are linked to adverse cardiovascular outcomes. The mitochondrial adaptor p66
DESIGN/METHODS
Altogether 158 subjects were included in the study (mean age 59.4 ± 7.0 years). Thirty-eight subjects were healthy active, 36 were healthy sedentary and 84 were sedentary with ≥2 cardiovascular risk factors. Retinal arteriolar and venular diameters were measured by means of a retinal vessel analyser. As a marker of oxidative stress, plasma 3-nitrotyrosine was determined by enzyme-linked immunosorbent assay. Gene expression of p66
RESULTS
Wider retinal arterioles (179 ± 14 vs 172 ± 11 and 171 ± 14 µm;
CONCLUSION
Long-term physical activity-induced DNA methylation of p66
Identifiants
pubmed: 31610708
doi: 10.1177/2047487319880367
doi:
Substances chimiques
Biomarkers
0
SHC1 protein, human
0
Src Homology 2 Domain-Containing, Transforming Protein 1
0
3-nitrotyrosine
3604-79-3
Tyrosine
42HK56048U
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
168-176Commentaires et corrections
Type : CommentIn