Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin.
CAR T cells
biochemistry
bioluminescence
chemical biology
dual imaging
infraluciferin
luciferase crystal structure
molecular biophysics
mouse
near infrared
structural biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
05
02
2019
accepted:
25
09
2019
pubmed:
16
10
2019
medline:
21
3
2020
entrez:
16
10
2019
Statut:
epublish
Résumé
Bioluminescence imaging (BLI) is ubiquitous in scientific research for the sensitive tracking of biological processes in small animal models. However, due to the attenuation of visible light by tissue, and the limited set of near-infrared bioluminescent enzymes, BLI is largely restricted to monitoring single processes in vivo. Here we show, that by combining stabilised colour mutants of firefly luciferase (FLuc) with the luciferin (LH
Identifiants
pubmed: 31610848
doi: 10.7554/eLife.45801
pii: 45801
pmc: PMC6828332
doi:
pii:
Substances chimiques
Luminescent Proteins
0
Recombinant Fusion Proteins
0
Banques de données
PDB
['6HPS']
Dryad
['10.5061/dryad.3j9kd51cs']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Foundation
ID : MCB-1410390
Pays : International
Organisme : Air Force Office of Scientific Research
ID : FA9550-18-1-0017
Pays : International
Organisme : Engineering and Physical Sciences Research Council
ID : EP/L504889/1
Pays : International
Informations de copyright
© 2019, Stowe et al.
Déclaration de conflit d'intérêts
CS, TB, HA, MV, GK, DC, GP, TS, GA, AH, ML, BB, TK, JA, MP No competing interests declared
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