Biology and therapeutic potential of interleukin-10.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
06 01 2020
06 01 2020
Historique:
received:
10
06
2019
revised:
05
08
2019
accepted:
11
09
2019
pubmed:
16
10
2019
medline:
14
7
2020
entrez:
16
10
2019
Statut:
ppublish
Résumé
The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from over-exuberant responses to pathogens and microbiota, while playing important roles in other settings as sterile wound healing, autoimmunity, cancer, and homeostasis. Here we discuss our current understanding of the regulation of IL-10 production and of the molecular pathways associated with IL-10 responses. In addition to IL-10's classic inhibitory effects on myeloid cells, we also describe the nonclassic roles attributed to this pleiotropic cytokine, including how IL-10 regulates basic processes of neural and adipose cells and how it promotes CD8 T cell activation, as well as epithelial repair. We further discuss its therapeutic potential in the context of different diseases and the outstanding questions that may help develop an effective application of IL-10 in diverse clinical settings.
Identifiants
pubmed: 31611251
pii: jem.20190418
doi: 10.1084/jem.20190418
pmc: PMC7037253
pii:
doi:
Substances chimiques
Cytokines
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001126
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001126
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U117565642
Pays : United Kingdom
Informations de copyright
© 2019 Saraiva et al.
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