A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor.

Analgesics, Opioid / chemistry Animals Binding Sites Cell Line, Tumor Fungal Proteins / chemistry HEK293 Cells Humans Mice Molecular Docking Simulation Oligopeptides / chemistry Penicillium / chemistry Protein Binding Receptors, Opioid, mu / agonists
biased agonist glycosylation opioid analgesic peptide drug μ-opioid receptor

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
29 10 2019
Historique:
pubmed: 16 10 2019
medline: 14 4 2020
entrez: 16 10 2019
Statut: ppublish

Résumé

An Australian estuarine isolate of

Identifiants

DOI: 10.1073/pnas.1908662116 PMID: 31611414 PMC: PMC6825270
pubmed: 31611414
pii: 1908662116
doi: 10.1073/pnas.1908662116
pmc: PMC6825270
doi:

Substances chimiques

Analgesics, Opioid 0
Fungal Proteins 0
Oligopeptides 0
Receptors, Opioid, mu 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

22353-22358

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

Competing interest statement: Patent Application(s) corresponding to Australian Patent Application 2018901944 The University of Sydney and The University of Queensland has been filed concerning this peptide. Title: Analgesics and Methods of Use Thereof.

Références

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Auteurs

Zoltan Dekan (Z)

Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia.
ORCID: 0000-0002-6841-4176

Setareh Sianati (S)

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, NSW 2006, Australia.

Arsalan Yousuf (A)

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, NSW 2006, Australia.

Katy J Sutcliffe (KJ)

Schools of Physiology, Pharmacology and Neuroscience, and Biochemistry, Biomedical Sciences Building, University of Bristol, BS8 1TD Bristol, United Kingdom.

Alexander Gillis (A)

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, NSW 2006, Australia.

Christophe Mallet (C)

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, NSW 2006, Australia.
ORCID: 0000-0002-0873-6763

Paramjit Singh (P)

Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia.

Aihua H Jin (AH)

Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia.

Anna M Wang (AM)

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, NSW 2006, Australia.

Sarasa A Mohammadi (SA)

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, NSW 2006, Australia.

Michael Stewart (M)

Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia.

Ranjala Ratnayake (R)

Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia.

Frank Fontaine (F)

Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia.

Ernest Lacey (E)

Microbial Screening Technologies Pty. Ltd., Smithfield, NSW, 2164, Australia.

Andrew M Piggott (AM)

Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia.
ORCID: 0000-0002-5308-5314

Yan P Du (YP)

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, NSW 2006, Australia.

Meritxell Canals (M)

Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, 3052 Parkville, Australia.

Richard B Sessions (RB)

Schools of Physiology, Pharmacology and Neuroscience, and Biochemistry, Biomedical Sciences Building, University of Bristol, BS8 1TD Bristol, United Kingdom.
ORCID: 0000-0003-0320-0895

Eamonn Kelly (E)

Schools of Physiology, Pharmacology and Neuroscience, and Biochemistry, Biomedical Sciences Building, University of Bristol, BS8 1TD Bristol, United Kingdom.

Robert J Capon (RJ)

Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia; r.capon@imb.uq.edu.au p.alewood@imb.uq.edu.au mac.christie@sydney.edu.au.

Paul F Alewood (PF)

Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia; r.capon@imb.uq.edu.au p.alewood@imb.uq.edu.au mac.christie@sydney.edu.au.

MacDonald J Christie (MJ)

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, NSW 2006, Australia; r.capon@imb.uq.edu.au p.alewood@imb.uq.edu.au mac.christie@sydney.edu.au.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Eucaryotes › Animaux › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Penicillium › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › A tetrapeptide class of biased analgesics from...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur mu › A tetrapeptide class of biased analgesics from...