Upregulation of SPDEF is associated with poor prognosis in prostate cancer.
ETS-related gene
SAM pointed domain-containing Ets transcription factor
deletion
prostate cancer
tissue microarray
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
04
03
2019
accepted:
16
07
2019
entrez:
16
10
2019
pubmed:
16
10
2019
medline:
16
10
2019
Statut:
ppublish
Résumé
SAM pointed domain-containing Ets transcription factor (SPDEF), a member of the ETS transcription factor family, has been associated with prostate cancer development; however, its role in tumour development and progression is controversial. In the present study, SPDEF expression was analysed on a tissue microarray with >12,000 prostate cancer samples. SPDEF expression levels were higher in most prostate cancer samples than in normal prostate epithelium, suggesting SPDEF was upregulated in cancer. Nuclear SPDEF expression was identified in 80% of prostate cancer samples, and considered weak in 26.4%, moderate in 40.1% and strong in 13.5% of cases. SPDEF positivity was significantly associated with tumour stage, Gleason grade, lymph node metastasis and PSA recurrence (all P<0.0001). SPDEF overexpression was more common in ERG positive (94%) than in ERG negative cancer (69%; P<0.0001). Elevated SPDEF expression predicted poor prognosis independent from established prognostic parameters, including Gleason grade, pT, pN, serum PSA level and nodal status (P<0.01). In summary, SPDEF overexpression was associated with aggressive behaviour, particularly in ERG negative prostate cancer, and may have potential for clinical application.
Identifiants
pubmed: 31612022
doi: 10.3892/ol.2019.10885
pii: OL-0-0-10885
pmc: PMC6781494
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5107-5118Informations de copyright
Copyright: © Meiners et al.
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