The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer.
MAPK
RAS
cancer
microRNA
target therapies
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
07
2019
accepted:
16
09
2019
entrez:
16
10
2019
pubmed:
16
10
2019
medline:
16
10
2019
Statut:
epublish
Résumé
microRNAs (miRNAs) regulate gene expression by modulating the translation of protein-coding RNAs. Their aberrant expression is involved in various human diseases, including cancer. Here, we summarize the experimental pieces of evidence that proved how dysregulated miRNA expression can lead to RAS (HRAS, KRAS, or NRAS) activation irrespective of their oncogenic mutations. These findings revealed relevant pathogenic mechanisms as well as mechanisms of resistance to target therapies. Based on this knowledge, potential approaches for the control of RAS oncogenic activation can be envisioned.
Identifiants
pubmed: 31612113
doi: 10.3389/fonc.2019.00988
pmc: PMC6777413
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
988Informations de copyright
Copyright © 2019 Roncarati, Lupini, Shankaraiah and Negrini.
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