A candidate-SNP retrospective cohort study for fracture risk in Japanese Thoroughbred racehorses.
MSTN
chip fracture
heritability
horse
horseracing
Journal
Animal genetics
ISSN: 1365-2052
Titre abrégé: Anim Genet
Pays: England
ID NLM: 8605704
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
accepted:
18
09
2019
pubmed:
16
10
2019
medline:
14
2
2020
entrez:
16
10
2019
Statut:
ppublish
Résumé
Fractures are medical conditions that compromise the athletic potential of horses and/or the safety of jockeys. Therefore, the reduction of fracture risk is an important horse and human welfare issue. The present study used molecular genetic approaches to determine the effect of genetic risk for fracture at four candidate SNPs spanning the myostatin (MSTN) gene on horse chromosome 18. Among the 3706 Japanese Thoroughbred racehorses, 1089 (29.4%) had experienced fractures in their athletic life, indicating the common occurrence of this injury in Thoroughbreds. In the case/control association study, fractures of the carpus (carpal bones and distal radius) were statistically associated with g.65809482T/C (P = 1.17 x 10
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-50Subventions
Organisme : Japan Racing Association
ID : JRA 2014-2016
Informations de copyright
© 2019 Stichting International Foundation for Animal Genetics.
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