Repositioning of Guanabenz in Conjugation with Gold and Silver Nanoparticles against Pathogenic Amoebae
Acanthamoeba castellanii
/ drug effects
Amebicides
/ chemistry
Cell Line
Drug Repositioning
Gold
/ chemistry
Guanabenz
/ chemistry
HeLa Cells
Humans
Metal Nanoparticles
Microscopy, Atomic Force
Molecular Structure
Naegleria fowleri
/ drug effects
Nanoconjugates
/ chemistry
Particle Size
Silver
/ chemistry
Trophozoites
/ drug effects
Acanthamoeba
Naegleria fowleri
brain-eating amoeba
guanabenz
nanomedicine
nanoparticles
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
13 12 2019
13 12 2019
Historique:
pubmed:
16
10
2019
medline:
28
7
2020
entrez:
16
10
2019
Statut:
ppublish
Résumé
Brain-eating amoebae cause devastating infections in the central nervous system of humans, resulting in a mortality rate of 95%. There are limited effective therapeutic options available clinically for treating granulomatous amoebic encephalitis and primary amoebic meningoencephalitis caused by
Identifiants
pubmed: 31612700
doi: 10.1021/acsinfecdis.9b00263
doi:
Substances chimiques
Amebicides
0
Nanoconjugates
0
Silver
3M4G523W1G
Gold
7440-57-5
Guanabenz
GGD30112WC
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2039-2046Subventions
Organisme : NIAID NIH HHS
ID : R01 AI124723
Pays : United States