Heterogeneous surface-modified nanoplatforms for the targeted therapy of haematological malignancies.
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
24
08
2019
revised:
26
09
2019
accepted:
01
10
2019
pubmed:
16
10
2019
medline:
4
5
2021
entrez:
16
10
2019
Statut:
ppublish
Résumé
Here, we focus on nanoparticle (NP)-based platforms for the targeted therapy of haematological malignancies (HMs), providing an overview of surface-modified nanoplatforms, such as aptamer-, metal-, nucleic acid-, toxin, and peptide-modified NPs, for the efficient targeting of tumor cells. We discuss NPs targeting subcellular compartments, including mitochondria, nucleus and Golgi apparatus, for enhanced therapy of HMs. We also review stimuli-responsive nanoplatforms for modulating site-specific release of drugs. We provide insight into alternative modes of therapy, such as phototherapy, gene therapy, dendritic cell (DC) therapy, and radiotherapy, highlighting recent advances in the treatment of HMs.
Identifiants
pubmed: 31614201
pii: S1359-6446(19)30384-8
doi: 10.1016/j.drudis.2019.10.001
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
160-167Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.