Probiotics Can Cure Oral Aphthous-Like Ulcers in Inflammatory Bowel Disease Patients: A Review of the Literature and a Working Hypothesis.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
11 Oct 2019
Historique:
received: 18 09 2019
revised: 08 10 2019
accepted: 10 10 2019
entrez: 17 10 2019
pubmed: 17 10 2019
medline: 25 2 2020
Statut: epublish

Résumé

Dysbiosis has been associated with the onset of several chronic autoimmune or inflammatory pathologies (e.g., inflammatory bowel diseases-IBD), because of its primary role in the establishment of a chronic inflammatory process leading to tissue damage. Inflammatory bowel diseases can even involve areas far away from the gut, such as the extraintestinal manifestations involving the oral cavity with the onset of aphthous-like ulcers (ALU). Studies carried out on animal models have shown that intestinal dysbiosis may be related to the development of autoimmune diseases, even if the mechanisms involved are not yet well known. The aim of this paper is to verify the hypothesis that in inflammatory bowel diseases patients, aphthous-like ulcers are the result of the concomitance of intestinal dysbiosis and other events, e.g., the microtraumas, occurring in the oral mucosa, and that

Identifiants

pubmed: 31614427
pii: ijms20205026
doi: 10.3390/ijms20205026
pmc: PMC6834154
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Francesco Cappello (F)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. francesco.cappello@unipa.it.
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy. francesco.cappello@unipa.it.

Francesca Rappa (F)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. francyrappa@hotmail.com.

Federica Canepa (F)

Department of Surgical, Oncological and Stomatological Disciplines, Sector of Oral Medicine, University of Palermo, 90127 Palermo, Italy. canepafederica86@gmail.com.

Francesco Carini (F)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. francesco.carini@unipa.it.

Margherita Mazzola (M)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. margheritamazzola@hotmail.it.

Giovanni Tomasello (G)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. giovanni.tomasello@unipa.it.

Giuseppe Bonaventura (G)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. giuseppe.bonaventura@unipa.it.

Giovanna Giuliana (G)

Department of Surgical, Oncological and Stomatological Disciplines, Sector of Oral Medicine, University of Palermo, 90127 Palermo, Italy. giovanna.giuliana@unipa.it.

Angelo Leone (A)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. angelo.leone@unipa.it.

Dario Saguto (D)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. dariosaguto@gmail.com.

Federica Scalia (F)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. scalia.fede@gmail.com.

Fabio Bucchieri (F)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. fabio.bucchieri@unipa.it.

Alberto Fucarino (A)

Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy. fucaro1984@gmail.com.

Giuseppina Campisi (G)

Department of Surgical, Oncological and Stomatological Disciplines, Sector of Oral Medicine, University of Palermo, 90127 Palermo, Italy. giuseppina.campisi@unipa.it.

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Classifications MeSH