Role of the Metal Center in the Modulation of the Aggregation Process of Amyloid Model Systems by Square Planar Complexes Bearing 2-(2'-pyridyl)benzimidazole Ligands.
amyloid aggregation
anti-aggregation properties
gold(III) compounds
metallodrugs
palladium(II) compounds
platinum(II) compounds
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
12 Oct 2019
12 Oct 2019
Historique:
received:
13
09
2019
revised:
09
10
2019
accepted:
10
10
2019
entrez:
17
10
2019
pubmed:
17
10
2019
medline:
17
10
2019
Statut:
epublish
Résumé
The effect of analogue Pd(II)-, Pt(II)-, and Au(III) compounds featuring 2-(2'-pyridyl)benzimidazole on the aggregation propensity of amyloid-like peptides derived from Aβ and from the C-terminal domain of nucleophosmin 1 was investigated. Kinetic profiles of aggregation were evaluated using thioflavin binding assays, whereas the interactions of the compounds with the peptides were studied by UV-Vis absorption spectroscopy and electrospray ionization mass spectrometry. The results indicate that the compounds modulate the aggregation of the investigated peptides using different mechanisms, suggesting that the reactivity of the metal center and the physicochemical properties of the metals (rather than those of the ligands and the geometry of the metal compounds) play a crucial role in determining the anti-aggregation properties.
Identifiants
pubmed: 31614832
pii: ph12040154
doi: 10.3390/ph12040154
pmc: PMC6958441
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Dalton Trans. 2018 Jul 31;47(30):10130-10138
pubmed: 30004541
Oncotarget. 2016 Sep 13;7(37):59129-59143
pubmed: 27494862
Dalton Trans. 2019 Oct 7;48(37):14027-14035
pubmed: 31490509
Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):967-978
pubmed: 29330024
Chemistry. 2011 Oct 4;17(41):11657-66
pubmed: 21910144
Dalton Trans. 2014 Mar 14;43(10):3911-21
pubmed: 24448551
Biochem J. 1995 Oct 1;311 ( Pt 1):1-16
pubmed: 7575439
Acta Biomater. 2018 Feb;67:147-155
pubmed: 29221856
Dalton Trans. 2008 Mar 14;(10):1312-22
pubmed: 18305843
Chemistry. 2010 Dec 3;16(45):13339-42
pubmed: 21031373
Proteins. 2005 Apr 1;59(1):72-9
pubmed: 15688445
Inorg Chem. 2016 Aug 15;55(16):7814-6
pubmed: 27482735
Biometals. 2017 Oct;30(5):733-746
pubmed: 28808810
Inorg Chem. 2011 May 16;50(10):4340-8
pubmed: 21504185
J Inorg Biochem. 2017 Jun;171:1-9
pubmed: 28282581
Dalton Trans. 2014 Dec 14;43(46):17483-8
pubmed: 25340580
Metallomics. 2014 Nov;6(11):2117-25
pubmed: 25273168
FEBS J. 2019 Jun;286(12):2311-2328
pubmed: 30921500
Eur J Med Chem. 2012 Jan;47(1):399-411
pubmed: 22119126
Proc Natl Acad Sci U S A. 2008 May 13;105(19):6813-8
pubmed: 18463291
FASEB J. 2015 Sep;29(9):3689-701
pubmed: 25977257
Angew Chem Int Ed Engl. 2017 Feb 13;56(8):1994-2015
pubmed: 27685198
Int J Mol Sci. 2019 Feb 14;20(4):null
pubmed: 30769904
Biochim Biophys Acta Proteins Proteom. 2017 Feb;1865(2):176-185
pubmed: 27865970
Chem Commun (Camb). 2014 Aug 7;50(61):8360-2
pubmed: 24943911
Proteins. 2007 Feb 15;66(3):707-15
pubmed: 17152078
Redox Biol. 2018 Apr;14:450-464
pubmed: 29080524
Biochim Biophys Acta Proteins Proteom. 2019 Jun;1867(6):637-644
pubmed: 30710643
Inorg Chem. 2019 Jan 7;58(1):8-17
pubmed: 30556393
Chem Soc Rev. 2014 Oct 7;43(19):6701-15
pubmed: 24671229
Metallomics. 2013 Jun;5(7):879-87
pubmed: 23689733
Int J Biol Macromol. 2019 Feb 1;122:517-525
pubmed: 30389521
Biochem Biophys Res Commun. 1992 May 15;184(3):1441-7
pubmed: 1590803
Inorg Chem. 2005 Mar 7;44(5):1332-43
pubmed: 15732973
J Inorg Biochem. 2015 Nov;152:114-22
pubmed: 26383119
Dalton Trans. 2004 Nov 7;(21):3678-88
pubmed: 15510293
J Neurosci Res. 2007 Feb 15;85(3):623-33
pubmed: 17131391
J Am Chem Soc. 2003 Dec 17;125(50):15359-65
pubmed: 14664580
Chem Soc Rev. 2013 Jun 21;42(12):5323-51
pubmed: 23450221
Biopolymers. 2006 Dec 5;83(5):508-18
pubmed: 16888773
Dalton Trans. 2018 Mar 6;47(10):3459-3468
pubmed: 29431787
Chem Rev. 2014 Apr 23;114(8):4540-63
pubmed: 24456146
Dalton Trans. 2015 Jun 14;44(22):10392-8
pubmed: 25974859